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Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives
Alternative TitleSynthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives
Zhang Shu Lan; Liu Ya Jing; Zhao Yan Fang; Guo Qiu Ting; Gong Ping
2010
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume21Issue:9Pages:1071-1074
AbstractA series of 1,4-substituted phthalazine derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB-231 cell lines in vitro. Among them, compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC(50) values from 1 nmol/L to 0.92 mu mol/L. A preliminary SAR study of these derivatives was performed. (C) 2010 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA series of 1,4-substituted phthalazine derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB-231 cell lines in vitro. Among them, compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC_(50) values from 1 nmol/L to 0.92 μmol/L. A preliminary SAR study of these derivatives was performed
Keyword1,4-DISUBSTITUTED PHTHALAZINES KINASE INHIBITOR ANGIOGENESIS POTENT 1,4-Substituted phthalazine Synthesis Cytotoxicity
Indexed ByCSCD
Language英语
CSCD IDCSCD:4037423
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151952
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhang Shu Lan,Liu Ya Jing,Zhao Yan Fang,et al. Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives[J]. CHINESE CHEMICAL LETTERS,2010,21(9):1071-1074.
APA Zhang Shu Lan,Liu Ya Jing,Zhao Yan Fang,Guo Qiu Ting,&Gong Ping.(2010).Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives.CHINESE CHEMICAL LETTERS,21(9),1071-1074.
MLA Zhang Shu Lan,et al."Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives".CHINESE CHEMICAL LETTERS 21.9(2010):1071-1074.
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