2型糖尿病伴原发性高血压患者的胰岛素抵抗的研究

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	2型糖尿病伴原发性高血压患者的胰岛素抵抗的研究
其他题名	Characteristics of insulin secretion and insulin resistance in subjects of type 2 diabetes with essential hypertension
	Gan Yu 1; Zhang Jin 1; Zhang Guofeng 1; Zheng Changhong 2; Meng xin 1
	2004
发表期刊	中国现代医学杂志
ISSN	1005-8982
卷号	14.0 期号:007 页码:11-14
摘要	目的研究2型糖尿病伴原发性高血压(T2DM+EH)患者的胰岛功能及胰岛素抵抗。方法应用BA—ELISA法测定96例正常糖耐量(NGT)、132例T2DM和148例T2DM+EM三个实验组的血清真胰岛素(TI)水平，并计算出胰岛素敏感性指数(IAI)、胰岛素抵抗指数(HomalIR)和β细胞功能指数(HBCI)。结果IAl分别为-244±083，-346±0．99和一3．98±068；HBCI分别为4_23±018，239±0．11和2．41±0．14；Homa—1IR分别为一0.67±0．83，035±(0．99和086±0．68。T2DM及T2DM+EH组IAI、HBCl均低于NGT组，经协方差分析，差异具有非常显著性(P 005)。结论2型糖尿病伴原发性高血压较单纯2型糖尿病胰岛素抵抗加重，姨岛素敏感性减低，而胰岛素β细胞分泌功能损害并无加重。
其他摘要	Objective: To research the characteristics of insulin secretion and insulin resistance (IR) in subjects of type 2 diabetes with essential hypertension. Method: The fasting serum true insulin (TI) were determined with BA-ELISA method, fasting serum immunoreactive insulin(IRI) with radioimmunoassay, fasting plasma glucose (FPG) with enzyme method in 96 subjects of impaired glucose tolerance (NGT), 132 subjects of type 2diabetes(T2DM) and 148 subjects of T2DM with essential hypertension(T2DM+EH), who did not undergone any antihypertensive treatments in two weeks. On the basis of FPG and TI or IRI, insulin secretion index (HBCI)and insulin resistance level (including Homa model insulin resistance index - IR and insulin sensitivity indexIAI ) were calculated. Results: There were significant differences in body mass index (BMI) among the three groups. TI value was higher in subjects with T2DM than that in subjects with NGT, but there was no significance between T2DM and NGT (P＞0.05). Subjects in T2DM+EH had higher TI level than those in T2DM and NGT, and there was significant difference among the three groups (P＜0.05). Other indexes were as follows: IAI -2.44±0.83 (NGT), -3.46±+0.99 (T2DM) and -3.98±+0.68 (T2DM+EH). HBCI 4.23±0.18(NGT), 2.39±0.11 (T2DM)and 2.41±+0.14 (T2DM+EH). HomaIR -0.67±+0.83 (NGT), 0.35±0.99 (T2DM) and 0.86±0.68(T2DM+EH). IAI and HBCI in T2DM and T2DM+EH groups were lower than those in NGT, and the differences were significant.HomaIR in T2DM and T2DM+EH groups was higher than those in NGT group, and the difference was significant. IAI in T2DM+EH group was significantly lower than that in T2DM group. HomaIR in T2DM+EH group was significantly higher than that in T2DM group. HBCI in T2DM+EH group was higher than that in T2DM group, but the difference was not significant. Conclusion: Insulin resistance is more serious and insulin sensitivity is lower in subjects of type 2 diabetes with essential hypertension than those in type 2 diabetes, while insulin secretion is not more serious in type 2 diabetes with essential hypertension.
关键词	真胰岛素 2型糖尿病原发性高血压胰岛素抵抗胰岛素分泌功能
收录类别	CSCD
语种	中文
CSCD记录号	CSCD:2053768
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/152025
专题	中国科学院金属研究所
作者单位	1.中国医科大学 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Gan Yu,Zhang Jin,Zhang Guofeng,等. 2型糖尿病伴原发性高血压患者的胰岛素抵抗的研究[J]. 中国现代医学杂志,2004,14.0(007):11-14.
APA	Gan Yu,Zhang Jin,Zhang Guofeng,Zheng Changhong,&Meng xin.(2004).2型糖尿病伴原发性高血压患者的胰岛素抵抗的研究.中国现代医学杂志,14.0(007),11-14.
MLA	Gan Yu,et al."2型糖尿病伴原发性高血压患者的胰岛素抵抗的研究".中国现代医学杂志 14.0.007(2004):11-14.