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Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury
Alternative TitleOptimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury
Li Fuyong1; Han Shuai1; Ma Yi2; Yi Fuxin3; Xu Xinmin2; Liu Yunhui1
2014
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume9Issue:2Pages:179-189
AbstractPercutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, compression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 +/- 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demyelination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experimental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percutaneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.
Other AbstractPercutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, compression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 ± 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demyelination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experimental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percutaneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.
KeywordGANGLION BALLOON COMPRESSION GASSERIAN GANGLION LONG-TERM NEUROPATHIC PAIN MICROVASCULAR DECOMPRESSION TIC-DOULOUREUX NEURALGIA MICROCOMPRESSION EXPERIENCE MANAGEMENT nerve regeneration peripheral nerve injury trigeminal neuralgia percutaneous microballoon compression trigeminal ganglion cell demyelination axons vascular endothelial growth factor neural regeneration
Indexed ByCSCD
Language英语
Funding Project[Shengjing Hospital, China Medical University, China]
CSCD IDCSCD:5057691
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/152179
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Peoples Hosp Liaoning Prov, Department Neurosurg 2, Shenyang, Liaoning Provin, Peoples R China
3.First Affiliated Hosp, Liaoning Med Coll, Department Neurosurg 1, Jinzhou, Liaoning Provin, Peoples R China
Recommended Citation
GB/T 7714
Li Fuyong,Han Shuai,Ma Yi,et al. Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury[J]. NEURAL REGENERATION RESEARCH,2014,9(2):179-189.
APA Li Fuyong,Han Shuai,Ma Yi,Yi Fuxin,Xu Xinmin,&Liu Yunhui.(2014).Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury.NEURAL REGENERATION RESEARCH,9(2),179-189.
MLA Li Fuyong,et al."Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury".NEURAL REGENERATION RESEARCH 9.2(2014):179-189.
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