IMR OpenIR
Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids
Alternative TitleDesign, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids
Meng Ying1; Zhang Hongwei1; Liu Zehua1; Zeng Shanchao1; Zhang Hongwei1; Sun Chiyu1; Zhang Lijuan1; Zhao Mingming1; Wang Guan2; Jiang Mengying2; Shi Wei2; Song Hongrui1
2014
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume30Issue:4Pages:624-631
AbstractA series of pyrrolopyrazinone-chalcone hybrids(12a-12q) was designed, synthesized and screened for their antitumor activity against SKOV-3, A549 and HeLa cell lines in vitro. Compared with the pyrrolopyrazinone(10a) and 5-fluorouracil(5-FU), nearly all the tested compounds showed significantly-improved antitumor activities. The most promising compounds 12e and 12k(IC50=0.25 and 0.88 mu mol/L) respectively show activities of 123 and 35 times that of compound 10a(IC50=30.74 mu mol/L) against HeLa cell line. The result reveals that the presence of chalcone moiety is beneficial to their activity and selectivity.
Other AbstractA series of pyrrolopyrazinone-chalcone hybrids(12a—12q) was designed, synthesized and screened for their antitumor activity against SKOV-3, A549 and HeLa cell lines in vitro. Compared with the pyrrolopyrazi-none(10a) and 5-fluorouracil(5-FU), nearly all the tested compounds showed significantly-improved antitumor activities. The most promising compounds 12e and 12k(IC_(50)=0.25 and 0.88 μmol/L) respectively show activities of 123 and 35 times that of compound 10a(IC_(50)=30.74 μmol/L) against HeLa cell line. The result reveals that the presence of chalcone moiety is beneficial to their activity and selectivity.
KeywordDERIVATIVES CELL HYDROXYCHALCONES AGENTS Pyrrolopyrazinone-chalcone hybrid Antitumor Marine sponge Combination principle
Indexed ByCSCD
Language英语
Funding Project[Program for Liaoning Innovative Research Team in University, China]
CSCD IDCSCD:5214900
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/152294
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.吉林大学
Recommended Citation
GB/T 7714
Meng Ying,Zhang Hongwei,Liu Zehua,et al. Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(4):624-631.
APA Meng Ying.,Zhang Hongwei.,Liu Zehua.,Zeng Shanchao.,Zhang Hongwei.,...&Song Hongrui.(2014).Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(4),624-631.
MLA Meng Ying,et al."Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.4(2014):624-631.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Meng Ying]'s Articles
[Zhang Hongwei]'s Articles
[Liu Zehua]'s Articles
Baidu academic
Similar articles in Baidu academic
[Meng Ying]'s Articles
[Zhang Hongwei]'s Articles
[Liu Zehua]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Meng Ying]'s Articles
[Zhang Hongwei]'s Articles
[Liu Zehua]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.