Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives

IMR OpenIR

	Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives
	Yu Fuqiang 1; Guan Aiying 2; Li Mengru 2; Hu Lan 2; Li Xiaowu 1
	2018
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	29 期号:6 页码:915-918
摘要	Employing the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified by H-1 NMR,C-13 NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB) and sorghum anthracnose (SA) were evaluated by the mycelium linear growth rate method. Compounds 4,16 and 20 displayed significant activities against RSB (EC50 = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC50 = 1.03 mg/L), equal to commercial pyraclostrobin (EC50= 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
其他摘要	Employing the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moietywere designed and synthesized. The structures of the title compounds were identified by ~1H NMR, ~(13)C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB)and sorghum anthracnose (SA)were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB (EC_(50) = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC_(50) = 1.03 mg/L), equal to commercial pyraclostrobin (EC_(50) = 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development.
关键词	INSECTICIDAL ACTIVITIES SAR 1,3,4-Oxadiazole derivatives Intermediate derivatization method Rice sheath blight Sorghum anthracnose Structure-activity relationship
收录类别	CSCD
语种	英语
资助项目	[Open Foundation of Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, China]
CSCD记录号	CSCD:6275686
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/152495
专题	中国科学院金属研究所
作者单位	1.上海市地震局 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Yu Fuqiang,Guan Aiying,Li Mengru,et al. Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives[J]. CHINESE CHEMICAL LETTERS,2018,29(6):915-918.
APA	Yu Fuqiang,Guan Aiying,Li Mengru,Hu Lan,&Li Xiaowu.(2018).Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives.CHINESE CHEMICAL LETTERS,29(6),915-918.
MLA	Yu Fuqiang,et al."Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives".CHINESE CHEMICAL LETTERS 29.6(2018):915-918.