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Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives
Alternative TitleDesign, Synthesis and Antifungal Activity of 6-Fluoro-3, 3a, 4, 5-tetrahydro-2H-pyrazolo 4, 3-c-quinoline-2-carboxamide Derivatives
Yuan Jing; Su Xin; Zhang Xin; Cong Lin; Guo Chun
2011
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume27Issue:6Pages:955-957
AbstractA series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-cquinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry(MS) and H-1 NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities, against the tested fungi at different levels.
Other AbstractA series of 6-fluoro-3, 3a, 4, 5-tetrahydro-2H-pyrazolo4, 3-cquinoline-2-carboxanide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry(MS) and 'H NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.
KeywordBIOLOGICAL-ACTIVITIES AGENTS 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-cquinoline-2-carboxamide derivative Cysteine protease inhibitor Antifungal activity
Indexed ByCSCD
Language英语
Funding Project[National Science and Technology Major Projects of China]
CSCD IDCSCD:4377190
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/152927
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Yuan Jing,Su Xin,Zhang Xin,et al. Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2011,27(6):955-957.
APA Yuan Jing,Su Xin,Zhang Xin,Cong Lin,&Guo Chun.(2011).Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,27(6),955-957.
MLA Yuan Jing,et al."Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 27.6(2011):955-957.
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