Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study

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	Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study
其他题名	Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study
	Jiang Wenyan; Yin Zhongmin; Pang Yixin; Wu Feng; Kong Lingtao; Xu Ke
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:15 页码:1151-1157
摘要	Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.
其他摘要	Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimenta findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.
关键词	VOXEL-BASED MORPHOMETRY ANTERIOR CINGULATE CORTEX RESTING-STATE FMRI TREATMENT-RESPONSE PREFRONTAL CORTEX NEURAL RESPONSE AMYGDALA FACES SAD 1ST-EPISODE major depressive disorder functional magnetic resonance imaging facial expression recognition antidepressant neural regeneration
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Liaoning Science and Technology Foundation] ; [Doctoral Foundation of the First Affiliated Hospital in China Medical University]
CSCD记录号	CSCD:4571280
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/152991
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Jiang Wenyan,Yin Zhongmin,Pang Yixin,et al. Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study[J]. NEURAL REGENERATION RESEARCH,2012,7(15):1151-1157.
APA	Jiang Wenyan,Yin Zhongmin,Pang Yixin,Wu Feng,Kong Lingtao,&Xu Ke.(2012).Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study.NEURAL REGENERATION RESEARCH,7(15),1151-1157.
MLA	Jiang Wenyan,et al."Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study".NEURAL REGENERATION RESEARCH 7.15(2012):1151-1157.