| Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study | |
| Alternative Title | Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study |
| Jiang Wenyan; Yin Zhongmin; Pang Yixin; Wu Feng; Kong Lingtao; Xu Ke | |
| 2012 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 7Issue:15Pages:1151-1157 |
| Abstract | Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder. |
| Other Abstract | Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimenta findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder. |
| Keyword | VOXEL-BASED MORPHOMETRY ANTERIOR CINGULATE CORTEX RESTING-STATE FMRI TREATMENT-RESPONSE PREFRONTAL CORTEX NEURAL RESPONSE AMYGDALA FACES SAD 1ST-EPISODE major depressive disorder functional magnetic resonance imaging facial expression recognition antidepressant neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Liaoning Science and Technology Foundation] ; [Doctoral Foundation of the First Affiliated Hospital in China Medical University] |
| CSCD ID | CSCD:4571280 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/152994 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Jiang Wenyan,Yin Zhongmin,Pang Yixin,et al. Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study[J]. NEURAL REGENERATION RESEARCH,2012,7(15):1151-1157. |
| APA | Jiang Wenyan,Yin Zhongmin,Pang Yixin,Wu Feng,Kong Lingtao,&Xu Ke.(2012).Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study.NEURAL REGENERATION RESEARCH,7(15),1151-1157. |
| MLA | Jiang Wenyan,et al."Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study".NEURAL REGENERATION RESEARCH 7.15(2012):1151-1157. |
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