Catalytic synthesis methods for triazolopyrimidine derivatives

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	Catalytic synthesis methods for triazolopyrimidine derivatives
其他题名	Catalytic Synthesis Methods for Triazolopyrimidine Derivatives
	Cheng ChunSheng; Gai YongMing; Wang XinLei; Peng Jun
	2008
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
卷号	26 期号:7 页码:1291-1294
摘要	A new method for catalyzed synthesis of triazolopyrimidine derivatives is reported. Alkylamine reaction with dialkyl cyanodithioiminocarbonate was catalyzed by quaternary ammonium salts at room temperature to yield 3-alkylamine-5-amino-1,2,4-triazole in good quality and high yields. After imidization and reaction with an alpha,beta-unsaturated acid derivative, the reaction intermediate was hydrolyzed in the presence of a Lewis acid to obtain the target product. This novel catalytic method for triazolopyrimidine derivatives can be carried out under inexpensive and mild conditions, and is safe and environmentally friendly. (1)H NMR results for all intermediates are reported.
其他摘要	A new method for catalyzed synthesis of triazolopyrimidine derivatives is reported. Alkylamine reaction with dialkyl cyanodithioiminocarbonate was catalyzed by quaternary ammonium salts at room temperature to yield 3-alkylamine-5-amino-1,2,4-triazole in good quality and high yields. After imidization and reaction with an ,-unsaturated acid derivative, the reaction intermediate was hydrolyzed in the presence of a Lewis acid to obtain the target product. This novel catalytic method for triazolopyrimidine derivatives can be carried out under inexpensive and mild conditions, and is safe and environmentally friendly. 1H NMR results for all intermediates are reported.
关键词	PARAQUAT triazolopyrimidine derivative catalyst Lewis acid green chemistry
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3434908
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/153774
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Cheng ChunSheng,Gai YongMing,Wang XinLei,et al. Catalytic synthesis methods for triazolopyrimidine derivatives[J]. CHINESE JOURNAL OF CHEMISTRY,2008,26(7):1291-1294.
APA	Cheng ChunSheng,Gai YongMing,Wang XinLei,&Peng Jun.(2008).Catalytic synthesis methods for triazolopyrimidine derivatives.CHINESE JOURNAL OF CHEMISTRY,26(7),1291-1294.
MLA	Cheng ChunSheng,et al."Catalytic synthesis methods for triazolopyrimidine derivatives".CHINESE JOURNAL OF CHEMISTRY 26.7(2008):1291-1294.