Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases

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	Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases
其他题名	Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases
	Gao Xinghua; Chen Hongduo
	2014
发表期刊	FRONTIERS OF MEDICINE
ISSN	2095-0217
卷号	8 期号:1 页码:1-5
摘要	Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39 degrees C to 40 degrees C) can modulate the activities of immune cells, including antigen-presenting cells, T cells, and natural killer cells. Heat shock temperature (41 degrees C to 43 degrees C) can increase the immunogenicity of tumor cells. Cytotoxic temperature (> 43 degrees C) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia.
其他摘要	Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39 ℃ to 40 ℃) can modulate the activities of immune cells, including antigen-presenting cells, Tcells, and natural killer cells. Heat shock temperature (41 ℃ to 43 ℃) can increase the immunogenicity of tumor cells. Cytotoxic temperature (> 43 ℃) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia.
关键词	hyperthermia HPV immune response virus tumor
收录类别	CSCD
语种	英语
资助项目	[Innovative Research Teams of Liaoning Department of Education] ; [Public Welfare Research Fund for Healthcare]
CSCD记录号	CSCD:5100113
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/153816
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Gao Xinghua,Chen Hongduo. Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases[J]. FRONTIERS OF MEDICINE,2014,8(1):1-5.
APA	Gao Xinghua,&Chen Hongduo.(2014).Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases.FRONTIERS OF MEDICINE,8(1),1-5.
MLA	Gao Xinghua,et al."Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases".FRONTIERS OF MEDICINE 8.1(2014):1-5.