A new and efficient method for the synthesis of rocuronium bromide

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	A new and efficient method for the synthesis of rocuronium bromide
其他题名	A new and efficient method for the synthesis of rocuronium bromide
	Wu XueYing 1; Wang YaoLing 2; Hai Li 2; Gong Ping 1; Wu Yong 2
	2017
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	28 期号:2 页码:487-492
摘要	Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant. In this work, a new and efficient route for preparing a key intermediate 2 beta-(4morpholiny1)-16 beta-(1-pyrrolidiny1)-5 alpha-androstan-3 alpha,17 beta-diol (6) was developed through a ring-opening of epoxide followed by introducing and pyrrolidine. Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%, which was higher than currently reported methods. Extraordinarily, this method would avoid the generation of disubstituted impurities E and F which are difficult to remove. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
其他摘要	Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant. In this work, a new and efficient route for preparing a key intermediate 2β-(4- morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-3α,17β-diol (6)was developed through a ring-opening of epoxide followed by introducing and pyrrolidine. Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%, which was higher than currently reported methods. Extraordinarily, this method would avoid the generation of disubstituted impurities E and F which are difficult to remove.
关键词	ULIPRISTAL ACETATE DERIVATIVES RECEPTORS THIAZOLE PYRAN HL-60 Rocuronium bromide 2 alpha,3 alpha-Epoxy steroid derivative NMBAs Fe-mediated New route
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation]
CSCD记录号	CSCD:5934409
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/153902
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.四川大学
推荐引用方式 GB/T 7714	Wu XueYing,Wang YaoLing,Hai Li,et al. A new and efficient method for the synthesis of rocuronium bromide[J]. CHINESE CHEMICAL LETTERS,2017,28(2):487-492.
APA	Wu XueYing,Wang YaoLing,Hai Li,Gong Ping,&Wu Yong.(2017).A new and efficient method for the synthesis of rocuronium bromide.CHINESE CHEMICAL LETTERS,28(2),487-492.
MLA	Wu XueYing,et al."A new and efficient method for the synthesis of rocuronium bromide".CHINESE CHEMICAL LETTERS 28.2(2017):487-492.