| A new and efficient method for the synthesis of rocuronium bromide | |
| Alternative Title | A new and efficient method for the synthesis of rocuronium bromide |
| Wu XueYing1; Wang YaoLing2; Hai Li2; Gong Ping1; Wu Yong2 | |
| 2017 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 28Issue:2Pages:487-492 |
| Abstract | Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant. In this work, a new and efficient route for preparing a key intermediate 2 beta-(4morpholiny1)-16 beta-(1-pyrrolidiny1)-5 alpha-androstan-3 alpha,17 beta-diol (6) was developed through a ring-opening of epoxide followed by introducing and pyrrolidine. Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%, which was higher than currently reported methods. Extraordinarily, this method would avoid the generation of disubstituted impurities E and F which are difficult to remove. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| Other Abstract | Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant. In this work, a new and efficient route for preparing a key intermediate 2β-(4- morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-3α,17β-diol (6)was developed through a ring-opening of epoxide followed by introducing and pyrrolidine. Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%, which was higher than currently reported methods. Extraordinarily, this method would avoid the generation of disubstituted impurities E and F which are difficult to remove. |
| Keyword | ULIPRISTAL ACETATE DERIVATIVES RECEPTORS THIAZOLE PYRAN HL-60 Rocuronium bromide 2 alpha,3 alpha-Epoxy steroid derivative NMBAs Fe-mediated New route |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation] |
| CSCD ID | CSCD:5934409 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/153905 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.四川大学 |
| Recommended Citation GB/T 7714 | Wu XueYing,Wang YaoLing,Hai Li,et al. A new and efficient method for the synthesis of rocuronium bromide[J]. CHINESE CHEMICAL LETTERS,2017,28(2):487-492. |
| APA | Wu XueYing,Wang YaoLing,Hai Li,Gong Ping,&Wu Yong.(2017).A new and efficient method for the synthesis of rocuronium bromide.CHINESE CHEMICAL LETTERS,28(2),487-492. |
| MLA | Wu XueYing,et al."A new and efficient method for the synthesis of rocuronium bromide".CHINESE CHEMICAL LETTERS 28.2(2017):487-492. |
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