Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents

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	Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents
其他题名	Design,Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents
	Zhang Lan; Deng Xinshan; Wu Jiaofeng; Meng Guangpeng; Liu Congchong; Chen Guzhou; Zhao Qingchun; Hu Chun
	2017
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	33 期号:3 页码:365-372
摘要	A series of N-(furan-2-ylmethyl)-1H-indole-3-carboxamide derivatives(6a- 6p) was designed and synthesized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor (EGFR), and the cytotoxic activities of the target compounds were evaluated against three EGFR high- expressed cancer cell lines human lung adenocarcinoma cell line(A549), Henrietta Lacks strain of cancer cell line(HeLa) and human colorectal cancer cell line(SW480)
其他摘要	A series of N-(furan-2-ylmethyl)-1H-indole-3-carboxamide derivatives(6a-6p) was designed and synthesized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor (EGFR), and the cytotoxic activities of the target compounds were evaluated against three EGFR high-expressed cancer cell linesfhuman lung adenocarcinoma cell line(A549), Henrietta Lacks strain of cancer cell line(HeLa) and human colorectal cancer cell line(SW480)
关键词	MOLECULAR TARGETED DRUGS TYROSINE KINASE CANCER-CELLS EGFR RESISTANCE POTENT DISCOVERY NSCLC Anticancer activity Epidemal growth factor receptor(EGFR) inhibitor N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Program for the Innovative Research Team of the Ministry of Education of China]
CSCD记录号	CSCD:6018836
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/154004
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhang Lan,Deng Xinshan,Wu Jiaofeng,et al. Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2017,33(3):365-372.
APA	Zhang Lan.,Deng Xinshan.,Wu Jiaofeng.,Meng Guangpeng.,Liu Congchong.,...&Hu Chun.(2017).Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,33(3),365-372.
MLA	Zhang Lan,et al."Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 33.3(2017):365-372.