Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats

IMR OpenIR

	Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats
其他题名	Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats
	Zhao Longshan; Yin Ran; Wei Binbin; Li Qing; Jiang Zhenyuan; Chen Xiaohui; Bi Kaishun
	2012
发表期刊	ACTA PHARMACOLOGICA SINICA
ISSN	1671-4083
卷号	33 期号:11 页码:1348-1352
摘要	Aim: To compare the pharmacokinetic parameters of cefuroxime lysine, a new second-generation of cephalosporin antibiotics, after intravenous (IV), intraperitoneal (IP), or intramuscular (IM) administration.
其他摘要	Aim: To compare the pharmacokinetic parameters of cefuroxime lysine, a new second-generation of cephalosporin antibiotics, after intravenous (IV), intraperitoneal (IP), or intramuscular (IM) administration. Methods: Twelve male and 12 virgin female Sprague-Dawley rats, weighing from 200 to 250 g, were divided into three groups ( n =4 for each gender in each group). The rats were administered a single dose (67.5 mg Results: After IV, IP or IM administration, the plasma cefuroxime lysine disposition was best described by a tri-compartmental, bi-compartmental or mono-compartmental open model, respectively, with first-order elimination. The plasma concentration profiles were similar through the 3 administration routes. The distribution process was rapid after IV administration t 1 , 0.10±0.11 h vs 1.36±0.65 and 1.25±1.01 h. The AUMC 0–∞ is markedly larger, and mean residence time (MRT) is greatly longer after IP administration than that in IV, or IM routes (AUMC 0–∞ : 55.33±20.34 vs 16.84±4.85 and 36.17±13.24 mg·h 2 vs 0.37±0.07 h and 0.65±0.05 h). The C max after IM injection was significantly higher than that in IP injection (73.51±12.46 vs 49.09±7.06 mg 0–∞ in male rats were significantly higher than that in female rats after IM administration (66.38±16.5 vs 44.23±6.37 mg·h Conclusion: Cefuroxime lysine shows quick absorption after IV injection, a long retension after IP injection, and a high C max after IM injection. After IM administration the AUC 0–∞ in male rats was significantly larger than that in female rats.
关键词	ANTIBACTERIAL ACTIVITY LIQUID-CHROMATOGRAPHY MODEL BIOAVAILABILITY ANTIBIOTICS ELIMINATION PLASMA DOSAGE AXETIL CATS cefuroxime lysine intravenous administration intramuscular administration intraperitoneal administration pharmacokinetics
收录类别	CSCD
语种	英语
资助项目	[National Key Scientific Project for New Drug Discovery and Development]
CSCD记录号	CSCD:4669573
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/154035
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhao Longshan,Yin Ran,Wei Binbin,et al. Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats[J]. ACTA PHARMACOLOGICA SINICA,2012,33(11):1348-1352.
APA	Zhao Longshan.,Yin Ran.,Wei Binbin.,Li Qing.,Jiang Zhenyuan.,...&Bi Kaishun.(2012).Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats.ACTA PHARMACOLOGICA SINICA,33(11),1348-1352.
MLA	Zhao Longshan,et al."Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats".ACTA PHARMACOLOGICA SINICA 33.11(2012):1348-1352.