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Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese
Alternative TitleAssociation of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese
Zhao Jiuhan1; Wang Xiaohong1; Xu Jialiang1; Li Nan2; Shang Xiuli1; He Zhiyi1; Yang Jun1
2012
Source PublicationACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN1672-9145
Volume44Issue:12Pages:1023-1030
AbstractAtherosclerosis is an important pathophysiological basis of atherothrombotic stroke (ATS), and inflammation plays a significant role in atherosclerosis formation. In this study, single-nucleotide polymorphisms (SNPs) in three key inflammation-related genes, 5-lipoxygenase activating protein (ALOX5AP), phosphodiesterase 4D (PDE4D), and interleukin-1 (IL-1), were investigated to determine their association with ATS in Northern Han Chinese. Six-hundred and eighty-two ATS patients and 598 unrelated controls were recruited. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and matrix-assisted laser desorption ionization time-of-flight mass spectrometry primer extension. The genotype and allele frequencies of each SNP were statistically analyzed. Risk of ATS was found for the ALOX5AP SG13S114A/T AA genotype (P 0.040) and A allele (P 0.033), PDE4D SNP83C/T TT genotype (P 0.010) and T allele (P 0.008) and SNP219A/G GG genotype (P 0.025) and G allele (P 0.022), and the IL-1-889C/T T allele (P 0.035). The differences still remained significant after adjustment. The ALOX5AP HapA haplotype was not correlated with ATS (P 0.834), but GCGA represented an at-risk haplotype (P 0.008). Furthermore, the PDE4D AA haplotype at SNP219-220 might be an at-risk haplotype (P 0.013), while GA might be a protective haplotype (P 0.005). The ALOX5AP (SG13S114A/T), PDE4D (SNP83C/T, 219A/G), and IL-1 (-889C/T) SNPs were associated with an increased risk of ATS in Northern Han Chinese.
Other AbstractAtherosclerosis is an important pathophysiological basis of atherothrombotic stroke (ATS), and inflammation plays a significant role in atherosclerosis formation. In this study, single-nucleotide polymorphisms (SNPs) in three key inflammation-related genes, 5-lipoxygenase activating protein (ALOX5AP), phosphodiesterase 4D (PDE4D), and interleu-kin-la (IL-la), were investigated to determine their association with ATS in Northern Han Chinese. Six-hundred and eighty-two ATS patients and 598 unrelated controls were recruited. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and matrix-assisted laser desorption ionization time-of-flight mass spectrometry primer extension. The genotype and allele frequencies of each SNP were statistically analyzed. Risk of ATS was found for the ALOX5AP SG13S114A/T AA genotype (P = 0.040) and A allele (P = 0.033), PDE4D SNP83C/T TT genotype (P = 0.010) and T allele (P= 0.008) and SNP219A/G GG genotype (P = 0.025) and G allele (P = 0.022), and the IL-1a-889C/T T allele (P = 0.035). The differences still remained significant after adjustment. The ALOX5AP HapA haplotype was not correlated with ATS (P = 0.834), but GCGA represented an at-risk haplotype (P = 0.008). Furthermore, the PDE4D AA haplotype at SNP219-220 might be an at-risk haplotype (P = 0.013), while GA might be a protective haplotype (P = 0.005). The ALOX5AP (SG13S114A/T), PDE4D (SNP83C/T, 219A/G), and IL-la (-889C/T) SNPs were associated with an increased risk of ATS in Northern Han Chinese.
Keyword5-LIPOXYGENASE ACTIVATING PROTEIN CAROTID-ARTERY ATHEROSCLEROSIS ISCHEMIC-STROKE PHOSPHODIESTERASE 4D MYOCARDIAL-INFARCTION CEREBRAL INFARCTION ALOX5AP GENE PDE4D GENE POPULATION RISK inflammation polymorphism atherothrombotic stroke ALOX5AP PDE4D
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:4708879
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/154237
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Jinzhou Cent Hosp, Department Neurol, Jinzhou 121000, Peoples R China
Recommended Citation
GB/T 7714
Zhao Jiuhan,Wang Xiaohong,Xu Jialiang,et al. Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(12):1023-1030.
APA Zhao Jiuhan.,Wang Xiaohong.,Xu Jialiang.,Li Nan.,Shang Xiuli.,...&Yang Jun.(2012).Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(12),1023-1030.
MLA Zhao Jiuhan,et al."Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.12(2012):1023-1030.
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