The RE single doped and co-doped TiO2 were prepared by sol-gel method,the structure and shape were characterized by XRD,FE-SEM. The photocatalytic activities were evaluated by degradation of methyl orange. The results show that the co-doping with optimum RE and metal can restrain the transform of anatase structure to rutile structure and the growth of crystal,improve the photocatalytic efficiency. The co-doping of RE and metal show a synergistic effect for photocatalytic activity of TiO2. The co-doped TiO2 show higher photocatalytic activity in degradation of methyl orange than that of single doped TiO2. Titania co-doped with La-Fe for n（La）：n（TiO2）=0.5%,n（Fe）：n（TiO2）=0.05% have the highest photocatalytic efficiency.