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Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration
Xie, Bei; Chen, Mengting; Ding, Pinghui; Lei, Lei; Zhang, Xing; Zhu, Dan; Zou, Yujian; Deng, Zhili; Sun, Guoming; Li, Ji; Nie, Hemin
2020-12-01
Source PublicationAPPLIED MATERIALS TODAY
Volume21
AbstractCurrent approaches fail at obtaining adequate functional human dermal papilla cells (DPCs) to regenerate hair follicles (HFs). Here we induce human dermal fibroblasts (hDFs) into hDPC-like cells (hDF-DPCs) through alginate-poly-L-lysine-alginate (APA) microencapsulation. Our results show that the derived hDF-DPCs are comparable to primary DPCs on the molecular level, and they can induce the formation of hair follicle-like structures and hair pigmentation in nude mice. RNA-seq analyses indicate the activation of Wnt signaling pathway during the hDF-DPCs conversion. Likewise, we demonstrate that mouse DFs differentiate into mouse DPC-like cells within the hydrogel microcapsules. The induction of dermal fibroblasts into DPC-like cells through biomimetic microencapsulation, devoid of chemical or gene reprogramming, would provide an alternative, abundant, and safe source of DPCs, which would help circumvent the bottleneck in DPC-based HF regeneration. (C) 2020 Elsevier Ltd. All rights reserved.
DOI10.1016/j.apmt.2020.100805
WOS IDWOS:000599826000001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/155652
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Xie, Bei,Chen, Mengting,Ding, Pinghui,et al. Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration[J]. APPLIED MATERIALS TODAY,2020,21.
APA Xie, Bei.,Chen, Mengting.,Ding, Pinghui.,Lei, Lei.,Zhang, Xing.,...&Nie, Hemin.(2020).Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration.APPLIED MATERIALS TODAY,21.
MLA Xie, Bei,et al."Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration".APPLIED MATERIALS TODAY 21(2020).
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