Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration

doi:10.1016/j.apmt.2020.100805

IMR OpenIR

	Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration
	Xie, Bei; Chen, Mengting; Ding, Pinghui; Lei, Lei; Zhang, Xing; Zhu, Dan; Zou, Yujian; Deng, Zhili; Sun, Guoming; Li, Ji; Nie, Hemin
	2020-12-01
发表期刊	APPLIED MATERIALS TODAY
卷号	21
摘要	Current approaches fail at obtaining adequate functional human dermal papilla cells (DPCs) to regenerate hair follicles (HFs). Here we induce human dermal fibroblasts (hDFs) into hDPC-like cells (hDF-DPCs) through alginate-poly-L-lysine-alginate (APA) microencapsulation. Our results show that the derived hDF-DPCs are comparable to primary DPCs on the molecular level, and they can induce the formation of hair follicle-like structures and hair pigmentation in nude mice. RNA-seq analyses indicate the activation of Wnt signaling pathway during the hDF-DPCs conversion. Likewise, we demonstrate that mouse DFs differentiate into mouse DPC-like cells within the hydrogel microcapsules. The induction of dermal fibroblasts into DPC-like cells through biomimetic microencapsulation, devoid of chemical or gene reprogramming, would provide an alternative, abundant, and safe source of DPCs, which would help circumvent the bottleneck in DPC-based HF regeneration. (C) 2020 Elsevier Ltd. All rights reserved.
DOI	10.1016/j.apmt.2020.100805
WOS记录号	WOS:000599826000001
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/155652
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Xie, Bei,Chen, Mengting,Ding, Pinghui,et al. Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration[J]. APPLIED MATERIALS TODAY,2020,21.
APA	Xie, Bei.,Chen, Mengting.,Ding, Pinghui.,Lei, Lei.,Zhang, Xing.,...&Nie, Hemin.(2020).Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration.APPLIED MATERIALS TODAY,21.
MLA	Xie, Bei,et al."Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration".APPLIED MATERIALS TODAY 21(2020).