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Growth of Dynamic Actin Filament via Brownian Dynamics Simulations
Alternative TitleGrowth of Dynamic Actin Filament via Brownian Dynamics Simulations
Guo Kunkun1; Han Wenchi2
2011
Source PublicationACTA CHIMICA SINICA
ISSN0567-7351
Volume69Issue:2Pages:145-152
AbstractActin polymerization is coupled with the hydrolysis of adenosine triphosphate (ATP). The hydrolysates of ATP are adenosine diphosphate (ADP) and inorganic phosphate (Pi). Therefore, each protomer within the actin filament can exhibit three different nucleotide states corresponding to bounded ATP, ADP/Pi and ADP molecules. These protomer states cause the filaments to form different spatial patterns, which will change various properties of the filament. The related model has been made to simulate the process of polymerization, depolymerization and hydrolysis via Brownian dynamics simulations, where the time evolution of depolymerization and hydrolysis is described as a continuous-time Markov process. In this paper, we focus on how to realize the chemical equilibrium between two ends of the filament, and study the growth behavior of long filaments as a function of ATP-actin monomer concentration.
KeywordPOLYMERIZATION KINETICS SYMMETRY-BREAKING MOTILITY DRIVEN CELL MOTILITY ADP-ACTIN MODEL TURNOVER brownian dynamics actin filament polymerization depolymerization
Indexed ByCSCD
Language英语
CSCD IDCSCD:4133426
Citation statistics
Cited Times:3[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/156003
Collection中国科学院金属研究所
Affiliation1.湖南大学
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Guo Kunkun,Han Wenchi. Growth of Dynamic Actin Filament via Brownian Dynamics Simulations[J]. ACTA CHIMICA SINICA,2011,69(2):145-152.
APA Guo Kunkun,&Han Wenchi.(2011).Growth of Dynamic Actin Filament via Brownian Dynamics Simulations.ACTA CHIMICA SINICA,69(2),145-152.
MLA Guo Kunkun,et al."Growth of Dynamic Actin Filament via Brownian Dynamics Simulations".ACTA CHIMICA SINICA 69.2(2011):145-152.
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