Ten new erythromycin antibacterial agents containing amidino group were designed and synthesized from erythromycin via oximation, reduction and condensation. Their structures were confirmed by MS and C-13 NMR; the synthetic condition (reaction medium)was explored; and their in vtiro antibacterial activities were tested. Compound HMA-3 showed antibacterial activity against staphylococcus aureus, which is equivalent to that of erythromycin A. Compounds HMA-8 and HMA-4 also showed an antibacterial activitiy. But no compound showed bactericidal activity.
其他摘要
Ten new erythromycin antibacterial agents containing amidino group were designed and synthesized from erythromycin via oximation, reduction and condensation. Their structures were confirmed by MS and 13C NMR; the synthetic condition(reaction medium)was explored; and their in vtiro antibacterial activities were tested. Compound HMA-3 showed antibacterial activity against staphylococcus aureus, which is equivalent to that of erythromycin A. Compounds HMA-8 and HMA-4 also showed an antibacterial activitiy. But no compound showed bactericidal activity.
Feng RL,Gong P,Fang L,et al. Synthesis and antibacterial activities of erythromycin derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2005,21(2):177-182.
APA
Feng RL,Gong P,Fang L,&Hong W.(2005).Synthesis and antibacterial activities of erythromycin derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,21(2),177-182.
MLA
Feng RL,et al."Synthesis and antibacterial activities of erythromycin derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 21.2(2005):177-182.
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