| Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China | |
| Alternative Title | Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China |
| Li Xinxu1; Jiang Shiwen1; Zhang Hui1; Jing Kuanhe2; Wang Li3; Li Weibin1; Liu Xiaoqiu1; Yao Hongyan4; Wang Lixia1 | |
| 2013 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 126Issue:19Pages:3662-3667 |
| Abstract | Background In county-level tuberculosis (TB) dispensaries in China, the accurate diagnosis of sputum smear-negative pulmonary tuberculosis (SNPT) needs to be improved by developing and validating clinical and radiographic predictors. |
| Other Abstract | Background In county-level tuberculosis (TB) dispensaries in China, the accurate diagnosis of sputum smear-negative pulmonary tuberculosis (SNPT) needs to be improved by developing and validating clinical and radiographic predictors. Methods The study was conducted simultaneously in three counties per province in Chongqing Municipality and Liaoning Province in China between May 2005 and May 2006. A total of 432 new SNPT patients who are HIV-negative and more than 15 years old diagnosed by expert panels in county-level TB dispensaries were recruited. Their sputum samples were collected for culture before anti-TB treatment, and the treatment outcomes (changes of X-rays) were followed up at the end of the 6th month. Results Of the 432 SNPT patients, sputum culture positive (9.7%) or culture negative with good changes of X-rays at the end of the 6th month (73.6%) was validated as SNPT. Four predictive variables were associated with validated SNPT in the multivariate logistic regression model: age ≤55 years old (odds ratio (OR) 5.66; 95% CI 2.69–11.91), >60 days of cough (OR 3.73; 95% CI 1.10–12.65), ≥10% of pulmonary consolidation in the lungs (OR 5.40; 95% CI 2.90–10.06), and pulmonary consolidation in the upper lobe anterior segment (OR 3.00; 95% CI 1.57–5.72). The area under the receiver operating characteristic curve of the model was 0.77 (95% CI 0.71–0.83). Conclusion Four predictors of clinical and radiological characteristics that had a good diagnostic performance of SNPT deserve to be recommended as index indicators of SNPT diagnosis in county-level TB dispensaries in China. |
| Keyword | ALGORITHM RISK validation study tuberculosis smear negative pulmonary/radiography |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [World Bank Loan/UK Department for International Development Grant Assistant China TB Control Project] ; [NTP in China] |
| CSCD ID | CSCD:4947334 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/156309 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 102206, Peoples R China Natl Ctr TB Control & Prevent 2.Chongqing Institute TB Prevent & Treatment, Chongqing 400050, Peoples R China 3.中国科学院金属研究所 4.Chinese Ctr Dis Control & Prevent, Off Epidemiol, Beijing 102206, Peoples R China Off Epidemiol |
| Recommended Citation GB/T 7714 | Li Xinxu,Jiang Shiwen,Zhang Hui,et al. Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China[J]. CHINESE MEDICAL JOURNAL,2013,126(19):3662-3667. |
| APA | Li Xinxu.,Jiang Shiwen.,Zhang Hui.,Jing Kuanhe.,Wang Li.,...&Wang Lixia.(2013).Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China.CHINESE MEDICAL JOURNAL,126(19),3662-3667. |
| MLA | Li Xinxu,et al."Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China".CHINESE MEDICAL JOURNAL 126.19(2013):3662-3667. |
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