Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China

IMR OpenIR

	Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China
其他题名	Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China
	Li Xinxu 1; Jiang Shiwen 1; Zhang Hui 1; Jing Kuanhe 2; Wang Li 3; Li Weibin 1; Liu Xiaoqiu 1; Yao Hongyan 4; Wang Lixia 1
	2013
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	126 期号:19 页码:3662-3667
摘要	Background In county-level tuberculosis (TB) dispensaries in China, the accurate diagnosis of sputum smear-negative pulmonary tuberculosis (SNPT) needs to be improved by developing and validating clinical and radiographic predictors.
其他摘要	Background In county-level tuberculosis (TB) dispensaries in China, the accurate diagnosis of sputum smear-negative pulmonary tuberculosis (SNPT) needs to be improved by developing and validating clinical and radiographic predictors. Methods The study was conducted simultaneously in three counties per province in Chongqing Municipality and Liaoning Province in China between May 2005 and May 2006. A total of 432 new SNPT patients who are HIV-negative and more than 15 years old diagnosed by expert panels in county-level TB dispensaries were recruited. Their sputum samples were collected for culture before anti-TB treatment, and the treatment outcomes (changes of X-rays) were followed up at the end of the 6th month. Results Of the 432 SNPT patients, sputum culture positive (9.7%) or culture negative with good changes of X-rays at the end of the 6th month (73.6%) was validated as SNPT. Four predictive variables were associated with validated SNPT in the multivariate logistic regression model: age ≤55 years old (odds ratio (OR) 5.66; 95% CI 2.69–11.91), >60 days of cough (OR 3.73; 95% CI 1.10–12.65), ≥10% of pulmonary consolidation in the lungs (OR 5.40; 95% CI 2.90–10.06), and pulmonary consolidation in the upper lobe anterior segment (OR 3.00; 95% CI 1.57–5.72). The area under the receiver operating characteristic curve of the model was 0.77 (95% CI 0.71–0.83). Conclusion Four predictors of clinical and radiological characteristics that had a good diagnostic performance of SNPT deserve to be recommended as index indicators of SNPT diagnosis in county-level TB dispensaries in China.
关键词	ALGORITHM RISK validation study tuberculosis smear negative pulmonary/radiography
收录类别	CSCD
语种	英语
资助项目	[World Bank Loan/UK Department for International Development Grant Assistant China TB Control Project] ; [NTP in China]
CSCD记录号	CSCD:4947334
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156309
专题	中国科学院金属研究所
作者单位	1.Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 102206, Peoples R China Natl Ctr TB Control & Prevent 2.Chongqing Institute TB Prevent & Treatment, Chongqing 400050, Peoples R China 3.中国科学院金属研究所 4.Chinese Ctr Dis Control & Prevent, Off Epidemiol, Beijing 102206, Peoples R China Off Epidemiol
推荐引用方式 GB/T 7714	Li Xinxu,Jiang Shiwen,Zhang Hui,et al. Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China[J]. CHINESE MEDICAL JOURNAL,2013,126(19):3662-3667.
APA	Li Xinxu.,Jiang Shiwen.,Zhang Hui.,Jing Kuanhe.,Wang Li.,...&Wang Lixia.(2013).Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China.CHINESE MEDICAL JOURNAL,126(19),3662-3667.
MLA	Li Xinxu,et al."Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China".CHINESE MEDICAL JOURNAL 126.19(2013):3662-3667.