Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10

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	Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10
其他题名	Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10
	Guo Rong 1; Huang Kui 1; Jiang Tongzi 1; Li Jian 2; Li Yu 1; Xing Xiaona 1; Cao Yunpeng 1
	2011
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	6 期号:26 页码:2005-2012
摘要	Immunotherapy for Alzheimer's disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 beta-amyloid (A beta) 1-42 vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a novel vaccine to avoid the T cell mediated immune response caused by the Ar beta(1-42). Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 x A beta(3-10) repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 x A beta(3-10) vaccine immunization, high titers of anti-A beta(42) IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 x A beta(3-10) immunized mice showed significantly improved memories compared to control mice. The 10 x A beta(3-10) vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 x A beta(3-10) vaccine might be more efficient if administered before A beta aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 x A beta(3-10) is a promising vaccine for AD.
其他摘要	Immunotherapy for Alzheimer’s disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 beta-amyloid (Aβ) 1-42 vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a novel vaccine to avoid the T cell mediated immune response caused by the Aβ1-42. Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 × Aβ3-10 repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 × Aβ3-10 vaccine immunization, high titers of anti-Aβ42 IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 × Aβ3-10 immunized mice showed significantly improved memories compared to control mice. The 10 × Aβ3-10 vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 × Aβ3-10 vaccine might be more efficient if administered before Aβ aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 × Aβ3-10 is a promising vaccine for AD
关键词	ALZHEIMERS-DISEASE MOUSE MODEL FOLLOW-UP PEPTIDE NEUROPATHOLOGY A-BETA-1-40/42 VACCINATION IMMUNOGENS PATHOLOGY PROTEIN Alzheimer's disease immunotherapy gene vaccine amyloid plaque T cell immunity response neural regeneration
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:4363505
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156515
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Liaoning Med Coll, Affiliated Hosp 1, Department Neurol, Jinzhou 121001, Liaoning Provin, Peoples R China
推荐引用方式 GB/T 7714	Guo Rong,Huang Kui,Jiang Tongzi,et al. Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10[J]. NEURAL REGENERATION RESEARCH,2011,6(26):2005-2012.
APA	Guo Rong.,Huang Kui.,Jiang Tongzi.,Li Jian.,Li Yu.,...&Cao Yunpeng.(2011).Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10.NEURAL REGENERATION RESEARCH,6(26),2005-2012.
MLA	Guo Rong,et al."Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10".NEURAL REGENERATION RESEARCH 6.26(2011):2005-2012.