| Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10 | |
| Alternative Title | Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10 |
| Guo Rong1; Huang Kui1; Jiang Tongzi1; Li Jian2; Li Yu1; Xing Xiaona1; Cao Yunpeng1 | |
| 2011 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 6Issue:26Pages:2005-2012 |
| Abstract | Immunotherapy for Alzheimer's disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 beta-amyloid (A beta) 1-42 vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a novel vaccine to avoid the T cell mediated immune response caused by the Ar beta(1-42). Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 x A beta(3-10) repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 x A beta(3-10) vaccine immunization, high titers of anti-A beta(42) IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 x A beta(3-10) immunized mice showed significantly improved memories compared to control mice. The 10 x A beta(3-10) vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 x A beta(3-10) vaccine might be more efficient if administered before A beta aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 x A beta(3-10) is a promising vaccine for AD. |
| Other Abstract | Immunotherapy for Alzheimer’s disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 beta-amyloid (Aβ) 1-42 vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a novel vaccine to avoid the T cell mediated immune response caused by the Aβ1-42. Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 × Aβ3-10 repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 × Aβ3-10 vaccine immunization, high titers of anti-Aβ42 IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 × Aβ3-10 immunized mice showed significantly improved memories compared to control mice. The 10 × Aβ3-10 vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 × Aβ3-10 vaccine might be more efficient if administered before Aβ aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 × Aβ3-10 is a promising vaccine for AD |
| Keyword | ALZHEIMERS-DISEASE MOUSE MODEL FOLLOW-UP PEPTIDE NEUROPATHOLOGY A-BETA-1-40/42 VACCINATION IMMUNOGENS PATHOLOGY PROTEIN Alzheimer's disease immunotherapy gene vaccine amyloid plaque T cell immunity response neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] |
| CSCD ID | CSCD:4363505 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/156515 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Liaoning Med Coll, Affiliated Hosp 1, Department Neurol, Jinzhou 121001, Liaoning Provin, Peoples R China |
| Recommended Citation GB/T 7714 | Guo Rong,Huang Kui,Jiang Tongzi,et al. Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10[J]. NEURAL REGENERATION RESEARCH,2011,6(26):2005-2012. |
| APA | Guo Rong.,Huang Kui.,Jiang Tongzi.,Li Jian.,Li Yu.,...&Cao Yunpeng.(2011).Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10.NEURAL REGENERATION RESEARCH,6(26),2005-2012. |
| MLA | Guo Rong,et al."Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10".NEURAL REGENERATION RESEARCH 6.26(2011):2005-2012. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment