| Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives | |
| Alternative Title | Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives |
| Liao Huimin; Chong Liane; Tan Li; Chen Xiaodan; You Rui; Gong Ping | |
| 2014 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 30Issue:5Pages:759-763 |
| Abstract | A series of novel 5,7-diphenylimidazo1,2-apyridine derivatives was designed and synthesized. The in vitro cytotoxic activities of all the target compounds against human colorectal cancer(HT-29), human lung cancer(H460), human gastric cancer(MKN45) and human breast cancer(MDA-MB-231) cell lines were evaluated. The pharmacological results indicated that most of the target compounds showed moderate to excellent activities against the tested cell lines. The most promising compound 4h(0.20, 0.006, 0.08, 0.021 mu mol/L) was 2.6, 5.1, 3.6 and 21.9 times more active than EPC2407(0.52, 0.031, 0.29, 0.46 mu mol/L) against HT-29, H460, MKN45 and MDA-MB-231 cell lines, respectively. |
| Other Abstract | A series of novel 5,7-diphenylimidazo1,2-apyridine derivatives was designed and synthesized. The in vitro cytotoxic activities of all the target compounds against human colorectal cancer (HT-29), human lung can-cer (H460), human gastric cancer (MKN45) and human breast cancer (MDA-MB-231) cell lines were evaluated. The pharmacological results indicated that most of the target compounds showed moderate to excellent activities against the tested cell lines. The most promising compound 4h (0.20, 0.006, 0.08, 0.021 μmol/L) was 2.6, 5.1, 3.6 and 21.9 times more active than EPC2407 (0.52, 0.031, 0.29, 0.46 μmol/L) against HT-29, H460, MKN45 and MDA-MB-231 cell lines, respectively. |
| Keyword | AGENTS Imidazo1,2-apyridine Biological evaluation Antitumor activity |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] |
| CSCD ID | CSCD:5259969 |
| Citation statistics |
Cited Times:3[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/156538 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Liao Huimin,Chong Liane,Tan Li,et al. Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(5):759-763. |
| APA | Liao Huimin,Chong Liane,Tan Li,Chen Xiaodan,You Rui,&Gong Ping.(2014).Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(5),759-763. |
| MLA | Liao Huimin,et al."Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.5(2014):759-763. |
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