| Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura | |
| Alternative Title | Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura ☆ |
| Liu Ruozhuo1; Yu Shengyuan1; Li Fengpeng2; Qiu Enchao1 | |
| 2012 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 7Issue:25Pages:1931-1938 |
| Abstract | Cortical spreading depression can trigger migraine with aura and activate the trigeminal vascular system. To examine gene expression profiles in the spinal trigeminal nucleus in rats following cortical spreading depression-induced migraine with aura, a rat model was established by injection of 1 M potassium chloride, which induced cortical spreading depression. DNA microarray analysis revealed that, compared with the control group, the cortical spreading depression group showed seven upregulated genes-myosin heavy chain 1/2, myosin light chain 1, myosin light chain (phosphorylatable, fast skeletal muscle), actin alpha 1, homeobox B8, carbonic anhydrase 3 and an unknown gene. Two genes were downregulated-RGD1563441 and an unknown gene. Real-time quantitative reverse transcription-PCR and bioinformatics analysis indicated that these genes are involved in motility, cell migration, CO2/nitric oxide homeostasis and signal transduction. |
| Other Abstract | Cortical spreading depression can trigger migraine with aura and activate the trigeminal vascular system. To examine gene expression profiles in the spinal trigeminal nucleus in rats following cortical spreading depression-induced migraine with aura, a rat model was established by injection of 1 M potassium chloride, which induced cortical spreading depression. DNA microarray analysis revealed that, compared with the control group, the cortical spreading depression group showed seven upregulated genes–myosin heavy chain 1 2 |
| Keyword | CORTICAL SPREADING DEPRESSION NITRIC-OXIDE INDUCTION PARKIN HOXB8 RING migraine with aura cortical spreading depression spinal nucleus of trigeminal nerve nervous system potassium chloride gene expression cell migration ubiquitin degradation enzyme regeneration neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] |
| CSCD ID | CSCD:4648161 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/156626 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国人民解放军总医院 2.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Liu Ruozhuo,Yu Shengyuan,Li Fengpeng,et al. Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura[J]. NEURAL REGENERATION RESEARCH,2012,7(25):1931-1938. |
| APA | Liu Ruozhuo,Yu Shengyuan,Li Fengpeng,&Qiu Enchao.(2012).Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura.NEURAL REGENERATION RESEARCH,7(25),1931-1938. |
| MLA | Liu Ruozhuo,et al."Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura".NEURAL REGENERATION RESEARCH 7.25(2012):1931-1938. |
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