| Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia | |
| Alternative Title | Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia |
| Qin Haiming; Song Fulin; Han Hongguang; Qu Hong; Zhai Xingwen; Qin Bin; You Song | |
| 2011 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 6Issue:27Pages:2105-2111 |
| Abstract | The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data suggest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins. |
| Other Abstract | The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data suggest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins |
| Keyword | ARTERY OCCLUSION WATER CHANNELS EXTRACT EGB-761 EDEMA NEUROPROTECTION PERMEABILITY ASTROCYTES PROTECTION MEMBRANE INJURY bilobalide aquaporin brain edema permanent middle cerebral artery occlusion glial fibrillary acidic protein neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [General Hospital of Shenyang Military Area Command of Chinese PLA] ; [Foundation of General Hospital of Shenyang Military Area Command of Chinese PLA] |
| CSCD ID | CSCD:4363518 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/156681 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Qin Haiming,Song Fulin,Han Hongguang,et al. Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia[J]. NEURAL REGENERATION RESEARCH,2011,6(27):2105-2111. |
| APA | Qin Haiming.,Song Fulin.,Han Hongguang.,Qu Hong.,Zhai Xingwen.,...&You Song.(2011).Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia.NEURAL REGENERATION RESEARCH,6(27),2105-2111. |
| MLA | Qin Haiming,et al."Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia".NEURAL REGENERATION RESEARCH 6.27(2011):2105-2111. |
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