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Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives
Alternative TitleSynthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives
Fu Li Qiang1; Guo Xing Sheng2; Liu Xin1; He Hui Li1; Wang Yu Ling2; Yang Yu She1
2010
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume21Issue:5Pages:507-510
AbstractIn order to probe the effect of C-2(S)-substituted groups in the antibacterial activity. a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for then in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b. (C) 2010 Yu She Yang Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved
Other AbstractIn order to probe the effect of C-2(S)-substituted groups in the antibacterial activity, a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.
KeywordPATHOGENS Synthesis Pleuromutilin C-2(S)-substituted Antimicrobial activity
Indexed ByCSCD
Language英语
CSCD IDCSCD:3892707
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/156713
Collection中国科学院金属研究所
Affiliation1.中国科学院
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Fu Li Qiang,Guo Xing Sheng,Liu Xin,et al. Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives[J]. CHINESE CHEMICAL LETTERS,2010,21(5):507-510.
APA Fu Li Qiang,Guo Xing Sheng,Liu Xin,He Hui Li,Wang Yu Ling,&Yang Yu She.(2010).Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives.CHINESE CHEMICAL LETTERS,21(5),507-510.
MLA Fu Li Qiang,et al."Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives".CHINESE CHEMICAL LETTERS 21.5(2010):507-510.
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