Efficacy and tolerability of one-site versus two-site phaco-trabeculectomy: a meta-analysis of randomized controlled clinical trials

IMR OpenIR

	Efficacy and tolerability of one-site versus two-site phaco-trabeculectomy: a meta-analysis of randomized controlled clinical trials
其他题名	Efficacy and tolerability of one-site versus two-site phacotrabeculectomy: a meta-analysis of randomized controlled clinical trials
	Liu Henan; Chen Xiaolong; Li Xun; Nie Qingzhu; Zhu Ying
	2010
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	123 期号:15 页码:2111-2115
摘要	Background Phacotrabeculectomy can be performed using one-site or two-site incisions. This meta-analysis evaluated the efficacy and tolerability of one-site versus two-site phacotrabeculectomy in the treatment of patients with coexisting cataract and glaucoma.
其他摘要	Background Phacotrabeculectomy can be performed using one-site or two-site incisions. This meta-analysis evaluated the efficacy and tolerability of one-site versus two-site phacotrabeculectomy in the treatment of patients with coexisting cataract and glaucoma. Methods A comprehensive literature search was performed according to the Cochrane Collaboration methodology to identify randomized controlled clinical trials comparing one-site with two-site phacotrabeculectomy. Studies meeting our predefined criteria were included in the meta-analysis. Efficacy estimates were measured by weighted mean difference (WMD) for the percentage intraocular pressure (IOP) reduction from baseline to end point, relative risk (RR) for the proportion of patients with a best-corrected visual acuity (BCVA) of 0.5 or better after surgery and complete success rates. Tolerability estimates were measured by RR for adverse events. All of outcomes were reported with 95% confidence interval (95% CI). Data were synthesised by Stata 10.1 for Windows. Results Two-site phacotrabeculectomy was associated with greater reductions in IOP than the one-site procedure (WMD: -5.99, 95% CI: -10.74--1.24, P=0.01). A greater proportion of patients also achieved a BCVA of 0.5 or better (RR: 0.91, 95% CI: 0.74-1.12, P=0.36) and the target IOP without anti-glaucoma medication at the study end point (RR: 0.94, 95% CI: 0.83-1.07, P=0.34) after two-site than one-site phacotrabeculectomy, but the differences were not significant. There were no significant differences in adverse events between two surgical procedures. Conclusions Two-site phacotrabeculectomy is superior to one-site phacotrabeculectomy in reducing IOP, but other post-operative effects are similar. One-site and two-site phacotrabeculectomies have similar adverse event rates
关键词	OPEN-ANGLE GLAUCOMA INTRAOCULAR-PRESSURE CORNEAL PHACOEMULSIFICATION LENS IMPLANTATION COMBINED CATARACT PHACOTRABECULECTOMY SURGERY EYES 3-YEAR 1-SITE phacotrabeculectomy one-site two-site meta-analysis
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3966052
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156925
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Liu Henan,Chen Xiaolong,Li Xun,et al. Efficacy and tolerability of one-site versus two-site phaco-trabeculectomy: a meta-analysis of randomized controlled clinical trials[J]. CHINESE MEDICAL JOURNAL,2010,123(15):2111-2115.
APA	Liu Henan,Chen Xiaolong,Li Xun,Nie Qingzhu,&Zhu Ying.(2010).Efficacy and tolerability of one-site versus two-site phaco-trabeculectomy: a meta-analysis of randomized controlled clinical trials.CHINESE MEDICAL JOURNAL,123(15),2111-2115.
MLA	Liu Henan,et al."Efficacy and tolerability of one-site versus two-site phaco-trabeculectomy: a meta-analysis of randomized controlled clinical trials".CHINESE MEDICAL JOURNAL 123.15(2010):2111-2115.