| Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats | |
| Alternative Title | Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats |
| Shang Wen1; Han Ping1; Yang Chengbing1; Gu Xiaowen1; Zhang Wei1; Xu Liping1; Fu Shouting1; Su Dingfeng1; Xie Hehui1 | |
| 2011 | |
| Source Publication | ACTA PHARMACOLOGICA SINICA
 |
| ISSN | 1671-4083 |
| Volume | 32Issue:9Pages:1109-1115 |
| Abstract | Aim: To investigate the synergism of low-doses of amlodipine and irbesartan on reduction of blood pressure variability (BPV), amelioration of baroreflex sensitivity (BRS) and organ protection in spontaneously hypertensive rats (SHR). |
| Other Abstract | Aim: To investigate the synergism of low-doses of amlodipine and irbesartan on reduction of blood pressure variability (BPV), amelioration of baroreflex sensitivity (BRS) and organ protection in spontaneously hypertensive rats (SHR). Methods: The rats were administered amlodipine (1 mg·kg ?1 ·d ?1 ) alone, irbesartan (10 mg·kg ?1 ·d ?1 ) alone, or the combination of the two drugs for 4 months. The drugs were mixed into the rat chow. Blood pressure (BP) was continuously monitored in conscious animals. After the determination of BRS, the rats were killed for morphological evaluation of organ damages. Results: The combination of low-dose irbesartan and amlodipine had statistically significant synergism on reduction of BP and BPV, amelioration of BRS and organ protection in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was associated with the decrease in systolic BPV ( r =0.665, P <0.01); the decrease in aortic hypertrophy was associated with the increase in BRS ( r =0.656, P <0.01); and the amelioration in renal lesion was associated with the increase in BRS ( r =0.763, P <0.01) and the decrease in systolic BPV ( r =0.706, P <0.01). Conclusion: Long-term treatment with a combination of low-doses of amlodipine and irbesartan showed significant synergism on reduction of BP and BPV, restoration of BRS and organ protection in SHR. Besides BP reduction, the enhancement of BRS and reduction of BPV might contribute to the organ protection. |
| Keyword | BLOOD-PRESSURE VARIABILITY SINOAORTIC-DENERVATED RATS CALCIUM-CHANNEL BLOCKADE BAROREFLEX SENSITIVITY HEART-RATE VENTRICULAR HYPERTROPHY BARORECEPTOR REFLEX ARTERIAL-PRESSURE NERVOUS-SYSTEM CONSCIOUS RATS hypertension spontaneously hypertensive rats (SHR) amlodipine irbesartan hypertension end organ damage blood pressure variability baroreflex sensitivity |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Science and Technology Major Project] ; [National Natural Science Foundation of China] |
| CSCD ID | CSCD:4335557 |
| Citation statistics |
Cited Times:3[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/157344 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.安徽肥东花生原种场 2.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Shang Wen,Han Ping,Yang Chengbing,et al. Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats[J]. ACTA PHARMACOLOGICA SINICA,2011,32(9):1109-1115. |
| APA | Shang Wen.,Han Ping.,Yang Chengbing.,Gu Xiaowen.,Zhang Wei.,...&Xie Hehui.(2011).Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats.ACTA PHARMACOLOGICA SINICA,32(9),1109-1115. |
| MLA | Shang Wen,et al."Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats".ACTA PHARMACOLOGICA SINICA 32.9(2011):1109-1115. |
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