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Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson's disease in the northern Han Chinese population
Alternative TitleLack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson's disease in the northern Han Chinese population
Zhu Lanhui1; Luo Xiaoguang1; Zhou Yishu1; Li Fengrui1; Yang Yichun3; Ren Yan1; Pang Hao1
2012
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume125Issue:4Pages:588-592
AbstractBackground Parkinson's disease (PD) is an autosomally inherited neurodegenerative disease in elderly people. The etiology of PD has long been thought to be associated with both genetic and environmental factors. To explore potential genetic risk factors for PD in the northern Han Chinese population, we investigated three single nucleotide polymorphisms (SNPs) (rs4538475, rs11107 and rs12564040) in the BST1, PARK15 and PARK9 genes.
Other AbstractBackground Parkinson's disease (PD) is an autosomally inherited neurodegenerative disease in elderly people. The etiology of PD has long been thought to be associated with both genetic and environmental factors. To explore potential genetic risk factors for PD in the northern Han Chinese population, we investigated three single nucleotide polymorphisms (SNPs) (rs4538475, rs11107 and rs12564040) in the BST1, PARK15 and PARK9 genes. Methods Genomic DNA from 215 PD patients and 212 matched controls was amplified in two independent PCR systems and subsequently genotyped by digestion with the endonuclease PstI. Genetic parameter and association studies were carried out with SPSS 13.0 and PLINK 1.07 software. Results We could accurately detect all genotypes in the three loci with the PCR-RFLP or mismatched PCR-RFLP techniques. The observed heterozygosities of the rs4538475 and rs11107 loci in PD and control groups ranged from 0.460–0.481 and 0.410–0.441, in BST1, PARK15 respectively, while we detected no heterozygosity at the rs12564040 locus in PARK9. The similar distributions of genotypic frequency between both groups suggest that the three SNPs investigated in this study are unlikely to play roles as common risk factors or pathogenic mutations for PD in northern Han Chinese. Conclusion The SNPs investigated in the BST1, PARK15 and PARK9 genes associated with PD susceptibility are not associated with PD in the northern Han Chinese population.
KeywordGENOME-WIDE ASSOCIATION P-TYPE ATPASE PYRAMIDAL SYNDROME ATP13A2 MUTATIONS VARIANTS FBXO7 LOCI Parkinson disease PARK9 PARK15 BST1 genetic association studies
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:4440285
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/157450
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Baotou Med Coll, Department Forens Med, Baotou 014060, Inner Mongolia, Peoples R China
3.大连大学
Recommended Citation
GB/T 7714
Zhu Lanhui,Luo Xiaoguang,Zhou Yishu,et al. Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson's disease in the northern Han Chinese population[J]. CHINESE MEDICAL JOURNAL,2012,125(4):588-592.
APA Zhu Lanhui.,Luo Xiaoguang.,Zhou Yishu.,Li Fengrui.,Yang Yichun.,...&Pang Hao.(2012).Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson's disease in the northern Han Chinese population.CHINESE MEDICAL JOURNAL,125(4),588-592.
MLA Zhu Lanhui,et al."Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson's disease in the northern Han Chinese population".CHINESE MEDICAL JOURNAL 125.4(2012):588-592.
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