Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety

IMR OpenIR

	Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety
Alternative Title	Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety
	Zhang Bei; Zhao Yan Fang; Zhai Xin; Fan Wei Jie; Ren Jun Ling; Wu Chun Fu; Gong Ping
	2012
Source Publication	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
Volume	23 Issue:8 Pages:915-918
Abstract	A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized. All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line (HL-60), human lung adenocarcinoma epithelial cell line (A549) and human breast cancer cell line (MDA-MB-231) in vitro by standard MTT assay. The pharmacological results indicated that some compounds exhibited promising antitumor activities. Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC50 values of 0.13 mu mol/L, 0.7 mu mol/L and 0.5 mu mol/L, respectively. (C) 2012 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other Abstract	A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized.All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line(HL-60),human lung adenocarcinoma epithelial cell line(A549) and human breast cancer cell line(MDA-MB-231) in vitro by standard MTT assay.The pharmacological results indicated that some compounds exhibited promising antitumor activities.Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC values of 0.13 mmol/L,0.7 mmol/L and 0.5 mmol/L,respectively.
Keyword	RAF/MEK/ERK PATHWAY DUAL-ACTION INHIBITORS TARGETS SORAFENIB CANCER Diaryl ureas N-acylhydrazone Antiproliferative activities
Indexed By	CSCD
Language	英语
Funding Project	[National High Technology Research and Development Program ("863" Program) of China] ; [National Natural Science Foundation of China] ; [Shenyang Science and Technology Plan Projects]
CSCD ID	CSCD:4601190
Citation statistics	Cited Times:2[CSCD] [CSCD Record]
Document Type	期刊论文
Identifier	http://ir.imr.ac.cn/handle/321006/157579
Collection	中国科学院金属研究所
Affiliation	中国科学院金属研究所
Recommended Citation GB/T 7714	Zhang Bei,Zhao Yan Fang,Zhai Xin,et al. Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety[J]. CHINESE CHEMICAL LETTERS,2012,23(8):915-918.
APA	Zhang Bei.,Zhao Yan Fang.,Zhai Xin.,Fan Wei Jie.,Ren Jun Ling.,...&Gong Ping.(2012).Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety.CHINESE CHEMICAL LETTERS,23(8),915-918.
MLA	Zhang Bei,et al."Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety".CHINESE CHEMICAL LETTERS 23.8(2012):915-918.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院金属研究所机构知识库