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Genetic diversity of coronaviruses in Miniopterus fuliginosus bats
Alternative TitleGenetic diversity of coronaviruses in Miniopterus fuliginosus bats
Du Jiang1; Yang Li1; Ren Xianwen1; Zhang Junpeng3; Dong Jie1; Sun Lilian1; Zhu Yafang1; Yang Fan1; Zhang Shuyi4; Wu Zhiqiang1; Jin Qi1
2016
Source PublicationScience China. Life Sciences
ISSN1674-7305
Volume59Issue:6Pages:604-614
AbstractCoronaviruses, such as severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, pose significant public health threats. Bats have been suggested to act as natural reservoirs for both these viruses, and periodic monitoring of coronaviruses in bats may thus provide important clues about emergent infectious viruses. The Eastern bent-wing bat Miniopterus fuliginosus is distributed extensively throughout China. We therefore analyzed the genetic diversity of coronaviruses in samples of M. fuliginosus collected from nine Chinese provinces during 2011–2013. The only coronavirus genus found was Alphacoronavirus . We established six complete and five partial genomic sequences of alphacoronaviruses, which revealed that they could be divided into two distinct lineages, with close relationships to coronaviruses in Miniopterus magnater and Miniopterus pusillus . Recombination was confirmed by detecting putative breakpoints of Lineage 1 coronaviruses in M. fuliginosus and M. pusillus (Wu et al., 2015), which supported the results of topological and phylogenetic analyses. The established alphacoronavirus genome sequences showed high similarity to other alphacoronaviruses found in other Miniopterus species, suggesting that their transmission in different Miniopterus species may provide opportunities for recombination with different alphacoronaviruses. The genetic information for these novel alphacoronaviruses will improve our understanding of the evolution and genetic diversity of coronaviruses, with potentially important implications for the transmission of human diseases.
Other AbstractCoronaviruses, such as severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, pose significant public health threats. Bats have been suggested to act as natural reservoirs for both these viruses, and periodic monitoring of coronaviruses in bats may thus provide important clues about emergent infectious viruses. The Eastern bent-wing bat Miniopterus fuliginosus is distributed extensively throughout China. We therefore analyzed the genetic diversity of coronaviruses in samples of M. fuliginosus collected from nine Chinese provinces during 2011–2013. The only coronavirus genus found was Alphacoronavirus . We established six complete and five partial genomic sequences of alphacoronaviruses, which revealed that they could be divided into two distinct lineages, with close relationships to coronaviruses in Miniopterus magnater and Miniopterus pusillus . Recombination was confirmed by detecting putative breakpoints of Lineage 1 coronaviruses in M. fuliginosus and M. pusillus (Wu et al., 2015), which supported the results of topological and phylogenetic analyses. The established alphacoronavirus genome sequences showed high similarity to other alphacoronaviruses found in other Miniopterus species, suggesting that their transmission in different Miniopterus species may provide opportunities for recombination with different alphacoronaviruses. The genetic information for these novel alphacoronaviruses will improve our understanding of the evolution and genetic diversity of coronaviruses, with potentially important implications for the transmission of human diseases.
KeywordRESPIRATORY SYNDROME CORONAVIRUS AVIAN CORONAVIRUSES MAXIMUM-LIKELIHOOD PROTEIN FAMILIES COMPLETE GENOME RECOMBINATION VIRUS ALPHACORONAVIRUS BETACORONAVIRUS EXPRESSION coronavirus Miniopterus fuliginosus bat co-infection recombination
Indexed ByCSCD
Language英语
Funding Project[Program for Changjiang Scholars and Innovative Research Team in University of China] ; [National S&T Major Project "China Mega-Project for Infectious Disease" from China] ; [National Natural Science Foundation of China] ; [PUMC Youth Fund] ; [Fundamental Research Funds for the Central Universities]
CSCD IDCSCD:5712853
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/157761
Collection中国科学院金属研究所
Affiliation1.中国科学院系统生物学重点实验室
2.Peking Union Med Coll, Beijing 100176, Peoples R China
3.E China Normal Univ, Institute Estuarine & Coastal Res, State Key Lab Estuarine & Coastal Res, Shanghai 200062, Peoples R China
4.中国科学院金属研究所
5.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Du Jiang,Yang Li,Ren Xianwen,et al. Genetic diversity of coronaviruses in Miniopterus fuliginosus bats[J]. Science China. Life Sciences,2016,59(6):604-614.
APA Du Jiang.,Yang Li.,Ren Xianwen.,Zhang Junpeng.,Dong Jie.,...&Jin Qi.(2016).Genetic diversity of coronaviruses in Miniopterus fuliginosus bats.Science China. Life Sciences,59(6),604-614.
MLA Du Jiang,et al."Genetic diversity of coronaviruses in Miniopterus fuliginosus bats".Science China. Life Sciences 59.6(2016):604-614.
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