| Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects | |
| Alternative Title | Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects |
| Muheremu Aikeremujiang1; Sun Jungang4; Wang Xiyuan2; Zhang Fei3; Ao Qiang2; Peng Jiang5 | |
| 2016 | |
| Source Publication | Neural Regeneration Research
 |
| ISSN | 1673-5374 |
| Volume | 11Issue:4Pages:664-669 |
| Abstract | Given the anatomic complexity at the bifurcation point of a nerve trunk, enforced suturing between stumps can lead to misdirection of nerve axons, thereby resulting in adverse consequences. We assumed that Y-tube conduits injected with human umbilical cord stem cells could be an effective method to solve such problems, but studies focused on the best type of Y-tube conduit remain controversial. Therefore, the present study evaluated the applicability and efficacy of various types of Y-tube conduits containing human umbilical cord stem cells for treating rat femoral nerve defects on their bifurcation points. At 12 weeks after the bridging surgery that included treatment with different types of Y-tube conduits, there were no differences in quadriceps femoris muscle weight or femoral nerve ultrastructure. However, the Y-tube conduit group with longer branches and a short trunk resulted in a better outcome according to retrograde labeling and electrophysiological analysis. It can be concluded from the study that repairing a mixed nerve defect at its bifurcation point with Y-tube conduits, in particular those with long branches and a short trunk, is effective and results in good outcomes. |
| Keyword | nerve regeneration Neurology. Diseases of the nervous system RC346-429 peripheral nerve injury nerve conduit selective nerve regeneration chemotaxis human umbilical cord blood stem cell stem cell transplantation neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National High Technology Research and Development Program of China ("863" Program)] ; [National Natural Science Foundation of China] ; [National Basic Research Program of China (973 program)] |
| CSCD ID | CSCD:5690847 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/157819 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.清华大学 2.中国科学院金属研究所 3.Xinjiang Med University, Affiliated Hosp 5, Dept Orthoped, Urumqi, Xinjiang Uygur, Peoples R China 4.Peoples Hosp Xinjiang Uygur Autonomous Reg, Department Orthoped, Urumqi, Xinjiang Uygur, Peoples R China 5.Gen Hosp PLA, Institute Orthopaed, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Muheremu Aikeremujiang,Sun Jungang,Wang Xiyuan,et al. Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects[J]. Neural Regeneration Research,2016,11(4):664-669. |
| APA | Muheremu Aikeremujiang,Sun Jungang,Wang Xiyuan,Zhang Fei,Ao Qiang,&Peng Jiang.(2016).Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects.Neural Regeneration Research,11(4),664-669. |
| MLA | Muheremu Aikeremujiang,et al."Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects".Neural Regeneration Research 11.4(2016):664-669. |
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