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Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint
Alternative TitleDiagnosis of tumor-like polypoid lesions of gallbladder by serum proteomic fingerprint
Ge Chunlin1; Luan Fengming1; Ma Ning1; Li Yongzhe2; Hu Chaojun2; Li Ning2
2008
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume20Issue:4Pages:286-289
AbstractObjective: To search the specific serum proteins in tumor-like polypoid lesions of the gallbladder(PLG) patients. Methods: Surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) technique and WCX Magnetic Beads were used to detect the serum proteomic fingerprint of 23 patients with tumor-like PLG, 21 patients with non tumor-like PLG and 26 normal persons. Biomarker Wizard and Biomarker Patterns Software were used in combination to analyze the data. Results: In the preliminary screening, 22 representative specific proteins for tumor-like PLG were found. Seven specific proteins showed increased expression and 15 specific proteins showed decreased expression in the tumor-like PLG patients. Three specific proteins are selected for the diagnosis of the tumor-like PLG.. Conclusion: SELDI-TOF-MS technique can be used to select specific proteins for tumor-like PLG patients, which may be useful for the diagnosis of the tumor-like PLG and the differential diagnosis with the non tumor-like PLG.
Other AbstractObjective To search the specific serum proteins in tumor-like polypoid lesions of the gallbladder(PLG) patients. Methods Surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) technique and WCX Magnetic Beads were used to detect the serum proteomic fingerprint of 23 patients with tumor-like PLG, 21 patients with non tumor-like PLG and 26 normal persons. Biomarker Wizard and Biomarker Patterns Software were used in combination to analyze the data. Results In the preliminary screening, 22 representative specific proteins for tumor-like PLG were found. Seven specific proteins showed increased expression and 15 specific proteins showed decreased expression in the tumor-like PLG patients. Three specific proteins are selected for the diagnosis of the tumor-like PLG. Conclusion SELDI-TOF-MS technique can be used to select specific proteins for tumor-like PLG patients, which may be useful for the diagnosis of the tumor-like PLG and the differential diagnosis with the non tumor-like PLG.
KeywordFLIGHT MASS-SPECTROMETRY SELDI-TOF-MS CANCER IDENTIFICATION DISCOVERY BIOMARKERS CARCINOMA BREAST TIME Gallbladder disease Diagnosis Specific proteins Surface enhanced laser desorption/ionization time of flight mass spectrometry
Indexed ByCSCD
Language英语
Funding Project[Scientific Research Foundation of the High School from Education Department of Liaoning Province]
CSCD IDCSCD:3427191
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/158089
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Beijing Union Med Coll Hosp, Peking Union Med Coll, Department Clin Lab, Beijing 100730, Peoples R China
3.中国医学科学院
Recommended Citation
GB/T 7714
Ge Chunlin,Luan Fengming,Ma Ning,et al. Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(4):286-289.
APA Ge Chunlin,Luan Fengming,Ma Ning,Li Yongzhe,Hu Chaojun,&Li Ning.(2008).Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint.CHINESE JOURNAL OF CANCER RESEARCH,20(4),286-289.
MLA Ge Chunlin,et al."Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint".CHINESE JOURNAL OF CANCER RESEARCH 20.4(2008):286-289.
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