Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China

IMR OpenIR

	Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China
	Ding Sijia 1; Han Xiaohu 2; Li Jun 3; Gao Weifan 2; Chen Zeliang 2; Feng Youjun 3
	2018
发表期刊	SCIENCE BULLETIN
ISSN	2095-9273
卷号	63 期号:16 页码:1059-1066
摘要	An endemic multi-drug resistant ST117 E. coli isolate coproducing MCR-1 and 3 ESBL loci was, for the first time, detected from diseased chicken, Liaoning Province, in Northeast China, from 2011 to 2012. Whole-genome sequencing revealed 5 unique plasmids, namely pHXH-1, pHXH-2, pHXH-3, pHXH-4 and pHXH-5). Among them, pHXH1 and pHXH4 encode ESBL, and pHXH-5 mediates MCR-1 colistin resistance. The results indicate that the potentially-national dissemination of MCR-1-positive pathogens with pan-drug resistance proceeds via food chains. (C) 2018 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
其他摘要	An endemic multi-drug resistant ST117 E. coli isolate coproducing MCR-1 and 3 ESBL loci was, for the first time, detected from diseased chicken, Liaoning Province, in Northeast China, from 2011 to 2012. Wholegenome sequencing revealed 5 unique plasmids, namely pHXH-1, pHXH-2, pHXH-3, pHXH-4 and pHXH- 5). Among them, pHXH1 and pHXH4 encode ESBL, and pHXH-5 mediates MCR-1 colistin resistance. The results indicate that the potentially-national dissemination of MCR-1-positive pathogens with pan-drug resistance proceeds via food chains.
关键词	RESOLUTION CRYSTAL-STRUCTURE VI SECRETION KLEBSIELLA-PNEUMONIAE CATALYTIC DOMAIN BETA-LACTAMASE ANTIBIOTIC-RESISTANCE SALMONELLA-ENTERICA GENE MCR-1 PLASMID INFECTIONS Lipid A MCR-1 Colistin resistance Transferable resistance to polymyxin Intrinsic colistin resistance Gut bacteria Microbiome
收录类别	CSCD
语种	英语
资助项目	[National Key R&D Program of China] ; [National Key Basic Research Program of China] ; [National Natural Science Foundation of China] ; ["Young 1000 Talents" Award]
CSCD记录号	CSCD:6337004
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/158240
专题	中国科学院金属研究所
作者单位	1.Zhejiang Chinese Med University, Sch Stomatol, Hangzhou 310053, Zhejiang, Peoples R China Sch Stomatol 2.中国科学院金属研究所 3.浙江大学
推荐引用方式 GB/T 7714	Ding Sijia,Han Xiaohu,Li Jun,et al. Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China[J]. SCIENCE BULLETIN,2018,63(16):1059-1066.
APA	Ding Sijia,Han Xiaohu,Li Jun,Gao Weifan,Chen Zeliang,&Feng Youjun.(2018).Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China.SCIENCE BULLETIN,63(16),1059-1066.
MLA	Ding Sijia,et al."Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China".SCIENCE BULLETIN 63.16(2018):1059-1066.