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Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro
Li, Mingjun1,2; Nan, Li2; Liang, Chunyong1; Sun, Ziqing2; Yang, Lei1,3; Yang, Ke2
Corresponding AuthorYang, Lei(ylei@hebut.edu.cn) ; Yang, Ke(kyang@imr.ac.cn)
2021-01-30
Source PublicationJOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
Volume62Pages:139-147
AbstractEscherichia coli (E. coli) and Staphylococcus aureus (S. aureus) are the most typical pathogenic bacteria with a significantly high risk of bio-contamination, widely existing in hospital and public places. Recent studies on antibacterial materials and the related mechanisms have attracted more interests of researchers. However, the antibacterial behavior of materials is usually evaluated separately on the single bacterial strain, which is far from the practical condition. Actually, the interaction between the polymicrobial communities can promote the growing profile of bacteria, which may weaken the antibacterial effect of materials. In this work, a 420 copper-bearing martensitic stainless steel (420CuSS) was studied with respect to its antibacterial activity and the underlying mechanism in a co-culturing infection model using both E. coli and S. aureus. Observed via plating and counting colony forming units (CFU), Cu releasing, and material characterization, 420CuSS was proved to present excellent antibacterial performance against the mixed bacteria with an approximately 99.4 % of antibacterial rate. In addition, 420CuSS could effectively inhibit the biofilm formation on its surfaces, resulting from a synergistic antibacterial effect of Cu ions, Fe ions, reactive oxygen species (ROS), and proton consumption of bacteria. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
KeywordMixed bacterial strains E. coli S. aureus 420 Cu-bearing stainless steel Antibacterial mechanism
Funding OrganizationNational Natural Science Foundation of China ; National Basic Research Program of China ; National Key R&D Program of China
DOI10.1016/j.jmst.2020.05.030
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[51101154] ; National Natural Science Foundation of China[51631009] ; National Natural Science Foundation of China[51672184] ; National Natural Science Foundation of China[51371168] ; National Basic Research Program of China[2012CB619101] ; National Key R&D Program of China[2020YFC1107400]
WOS Research AreaMaterials Science ; Metallurgy & Metallurgical Engineering
WOS SubjectMaterials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS IDWOS:000601221700014
PublisherJOURNAL MATER SCI TECHNOL
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/158830
Collection中国科学院金属研究所
Corresponding AuthorYang, Lei; Yang, Ke
Affiliation1.Hebei Univ Technol, Ctr Hlth Sci & Engn, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China
2.Univ Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
3.Int Res Ctr Translat Orthopaed IRCTO, Suzhou, Peoples R China
Recommended Citation
GB/T 7714
Li, Mingjun,Nan, Li,Liang, Chunyong,et al. Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,62:139-147.
APA Li, Mingjun,Nan, Li,Liang, Chunyong,Sun, Ziqing,Yang, Lei,&Yang, Ke.(2021).Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,62,139-147.
MLA Li, Mingjun,et al."Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 62(2021):139-147.
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