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Biological Effects of a Three-Dimensionally Printed Ti6Al4V Scaffold Coated with Piezoelectric BaTiO3 Nanoparticles on Bone Formation
Liu, Wenwen1; Li, Xiaokang1; Jiao, Yilai2; Wu, Cong3; Guo, Shuo1; Xiao, Xin1; Wei, Xinghui1; Wu, Jie4; Gao, Peng5,6; Wang, Ning1; Lu, Yajie1; Tang, Zhen1; Zhao, Quanming1; Zhang, Jinsong1; Tang, Yufei3; Shi, Lei1; Guo, Zheng1
Corresponding AuthorTang, Yufei(guozheng@fmmu.edu.cn) ; Shi, Lei(shilei_med@163.com) ; Guo, Zheng(yftang@xaut.edu.cn)
2020-11-18
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume12Issue:46Pages:51885-51903
AbstractBone defect repair at load-bearing sites is a challenging clinical problem for orthopedists. Defect reconstruction with implants is the most common treatment; however, it requires the implant to have good mechanical properties and the capacity to promote bone formation. In recent years, the piezoelectric effect, in which electrical activity can be generated due to mechanical deformation, of native bone, which promotes bone formation, has been increasingly valued. Therefore, implants with piezoelectric effects have also attracted great attention from orthopedists. In this study, we developed a bioactive composite scaffold consisting of BaTiO3, a piezoelectric ceramic material, coated on porous Ti6Al4V. This composite scaffold showed not only appropriate mechanical properties, sufficient bone and blood vessel ingrowth space, and a suitable material surface topography but also a reconstructed electromagnetic microenvironment. The osteoconductive and osteoinductive properties of the scaffold were reflected by the proliferation, migration, and osteogenic differentiation of mesenchymal stem cells. The ability of the scaffold to support vascularization was reflected by the proliferation and migration of human umbilical vein endothelial cells and their secretion of VEGF and PDGF-BB. A well-established sheep spinal fusion model was used to evaluate bony fusion in vivo. Sheep underwent implantation with different scaffolds, and X-ray, micro-computed tomography, van Gieson staining, and elemental energy-dispersive spectroscopy were used to analyze bone formation. Isolated cervical angiography and visualization analysis were used to assess angiogenesis at 4 and 8 months after transplantation. The results of cellular and animal studies showed that the piezoelectric effect could significantly reinforce osteogenesis and angiogenesis. Furthermore, we also discuss the molecular mechanism by which the piezoelectric effect promotes osteogenic differentiation and vascularization. In summary, Ti6Al4V scaffold coated with BaTiO3 is a promising composite biomaterial for repairing bone defects, especially at load-bearing sites, that may have great clinical translation potential.
Keywordtissue engineering porous Ti6Al4V scaffold barium titanate piezoelectric effect osteogenesis angiogenesis
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; Incubation Project of the Army's Medical Technology Youth Cultivation Program of China
DOI10.1021/acsami.0c10957
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2017YFC1104901] ; National Natural Science Foundation of China[51771227] ; National Natural Science Foundation of China[51871239] ; National Natural Science Foundation of China[81772328] ; Incubation Project of the Army's Medical Technology Youth Cultivation Program of China[17QNP021]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000592923100076
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/158967
Collection中国科学院金属研究所
Corresponding AuthorTang, Yufei; Shi, Lei; Guo, Zheng
Affiliation1.Fourth Mil Med Univ, Xijing Hosp, Dept Orthopaed, Xian 710032, Shaanxi, Peoples R China
2.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China
3.Xian Univ Technol, Dept Mat Sci & Engn, Xian 710048, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Med Ctr 8, Beijing 100091, Peoples R China
5.Hunan Normal Univ, Dept Joint Surg & Sports Med, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China
6.Hunan Normal Univ, Affiliated Hosp 1, Changsha 410016, Peoples R China
Recommended Citation
GB/T 7714
Liu, Wenwen,Li, Xiaokang,Jiao, Yilai,et al. Biological Effects of a Three-Dimensionally Printed Ti6Al4V Scaffold Coated with Piezoelectric BaTiO3 Nanoparticles on Bone Formation[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(46):51885-51903.
APA Liu, Wenwen.,Li, Xiaokang.,Jiao, Yilai.,Wu, Cong.,Guo, Shuo.,...&Guo, Zheng.(2020).Biological Effects of a Three-Dimensionally Printed Ti6Al4V Scaffold Coated with Piezoelectric BaTiO3 Nanoparticles on Bone Formation.ACS APPLIED MATERIALS & INTERFACES,12(46),51885-51903.
MLA Liu, Wenwen,et al."Biological Effects of a Three-Dimensionally Printed Ti6Al4V Scaffold Coated with Piezoelectric BaTiO3 Nanoparticles on Bone Formation".ACS APPLIED MATERIALS & INTERFACES 12.46(2020):51885-51903.
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