Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition

doi:10.1016/j.jmst.2020.06.001

IMR OpenIR

	Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition
	Chen, Kai 1; Tong, Changci 2; Yang, Jinge 3; Cong, Peifang 2; Liu, Ying 2; Shi, Xiuyun 2; Liu, Xu 2; Zhang, Jun 4; Zou, Rufei 5; Xiao, Keshen 5; Ni, Yuyang 1; Xu, Lei 5; Hou, Mingxiao 2; Jin, Hongxu 2; Liu, Yunen 2
通讯作者	Hou, Mingxiao(houmingxiao188@163.com) ; Jin, Hongxu(cszx_jhx@163.com) ; Liu, Yunen(lye9901@163.com)
	2021-02-10
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	63 页码:236-245
摘要	Carboxymethyl chitosan (CMCS)-based hydrogels have antibacterial activity, and have shown the abilities of preventing wound infection, promoting cell proliferation, accelerating collagen deposition, and stimulating hyaluronic acid formation during wound healing. As a hormone produced by the pineal gland in humans and animals, melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells, angiogenesis, and collagen deposition. However, the combined effects of CMCS and melatonin on wound healing remain unclear. Injectable CMCS-based hydrogels containing melatonin were prepared, and their healing effects were evaluated using a full-thickness cutaneous wound model in rats. Compared with the control and the hydrogel with no melatonin groups, the melatonin-loaded hydrogel significantly increased the percentage of wound closure, promoted the proliferation of granulation tissue and re-epithelialization, and accelerated collagen deposition. Additionally, the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide synthase. The melatonin-loaded hydrogel also markedly increased the expression of collagen III, a-smooth muscle actin, and transforming growth factor-(31 proteins and reduced collagen I expression. These results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Carboxymethyl chitosan Injectable melatonin-containing hydrogel Wound healing Antiinflammatory Angiogenesis Collagen deposition
资助者	National Natural Science Foundation of China ; Key R&D Projects of Science and Technology Department in Jiangxi Province ; PLA fundation of China ; Project of Science and Technology of Jiangxi ; Open Project of State Key Laboratory of Supramolecular Structure and Materials
DOI	10.1016/j.jmst.2020.06.001
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U1608255] ; Key R&D Projects of Science and Technology Department in Jiangxi Province[20192BBGL70032] ; PLA fundation of China[AWS15J004-2-1] ; Project of Science and Technology of Jiangxi[20171BAB216038] ; Open Project of State Key Laboratory of Supramolecular Structure and Materials
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000608708100025
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：45[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/159024
专题	中国科学院金属研究所
通讯作者	Hou, Mingxiao; Jin, Hongxu; Liu, Yunen
作者单位	1.Shangrao Normal Univ, Coll Life Sci, Innovat Inst Agr Technol, Shangrao 334001, Peoples R China 2.Gen Hosp Northern Theater Command, Lab Rescue Ctr Severe Trauma PLA, Dept Emergency Med, Shenyang 110016, Peoples R China 3.Jiangxi Med Coll, Shangrao 334001, Peoples R China 4.Yanshan Univ, Coll Phys Educ, Qinhuangdao 066004, Hebei, Peoples R China 5.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Chen, Kai,Tong, Changci,Yang, Jinge,et al. Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,63:236-245.
APA	Chen, Kai.,Tong, Changci.,Yang, Jinge.,Cong, Peifang.,Liu, Ying.,...&Liu, Yunen.(2021).Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,63,236-245.
MLA	Chen, Kai,et al."Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 63(2021):236-245.