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Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine
Yuan, Xiaoxue1,2; Liu, Ran4; Zhang, Wenchang1,2; Song, Xiaoqiang1,2; Xu, Lei1; Zhao, Yan1; Shang, Lei3; Zhang, Jingsong1
Corresponding AuthorZhao, Yan(yanzhao@imr.ac.cn) ; Shang, Lei(shanglei6677@163.com) ; Zhang, Jingsong(jshzhang@imr.ac.cn)
2021-02-10
Source PublicationJOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
Volume63Pages:210-215
AbstractControlled drug release technology is becoming a commercially sound methodology of administering pharmaceutical therapies, and it is important to predict and control the release kinetics to fully take advantage of this technology. Carboxylmethylchitosan (CMCS) and alginate (SA) blend membranes were successfully prepared by solution casting technique and exposing to acetic acid atmosphere, which induced the protonation of the amino groups of CMCS, and the formation of polyelectrolyte composite hydrogels. By using diclofenac diethylamine as the model drug, the diffusion controlled drug release behaviors of the membranes were studied based on permeation experiment, which indicated that the swelling rates of the membranes could be adjusted by simply changing the weight ratio of CMCS/SA and effectively changed the release rate of the membrane. The study shows that CMCS/SA blend membranes are promising biomaterials used for modulating the permeation behavior and developing advanced drug delivery systems. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
KeywordPolyelectrolyte complex hydrogel Carboxymethyl chitosan Alginate Diffusion controlled release
Funding OrganizationNational Natural Science Foundation of China
DOI10.1016/j.jmst.2020.05.008
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[U1608255]
WOS Research AreaMaterials Science ; Metallurgy & Metallurgical Engineering
WOS SubjectMaterials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS IDWOS:000608708100022
PublisherJOURNAL MATER SCI TECHNOL
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/159036
Collection中国科学院金属研究所
Corresponding AuthorZhao, Yan; Shang, Lei; Zhang, Jingsong
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
3.Shenyang Med Coll, Sch Pharm, Shenyang 110034, Peoples R China
4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Xiaoxue,Liu, Ran,Zhang, Wenchang,et al. Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,63:210-215.
APA Yuan, Xiaoxue.,Liu, Ran.,Zhang, Wenchang.,Song, Xiaoqiang.,Xu, Lei.,...&Zhang, Jingsong.(2021).Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,63,210-215.
MLA Yuan, Xiaoxue,et al."Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 63(2021):210-215.
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