| Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits | |
| Chow, Dick Ho Kiu1,2; Wang, Jiali1,2; Wan, Peng3,4; Zheng, Lizhen1,2; Ong, Michael Tim Yun1; Huang, Le1,2; Tong, Wenxue1,2; Tan, Lili3; Yang, Ke3; Qin, Ling1,2 | |
| 通讯作者 | Qin, Ling(lingqin@cuhk.edu.hk) |
| 2021-11-01 | |
| 发表期刊 | BIOACTIVE MATERIALS
 |
| 卷号 | 6期号:11页码:4176-4185 |
| 摘要 | Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity. Fracture fixation with biodegradable magnesium (Mg) pins enhanced fracture healing. We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically, mechanically, and histologically. Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits. The fracture was fixed with a pin made of stainless steel or pure Mg, and a figure-of-eight stainless steel band wire. Samples were harvested at week 8 or 12, and assessed with microCT, tensile testing, microindentation, and histology. Microarchitectural analysis showed that Mg group showed 12% higher in the ratio of bone volume to tissue volume at week 8, and 38.4% higher of bone volume at week 12. Tensile testing showed that the failure load and stiffness of Mg group were 66.9% and 104% higher than the control group at week 8, respectively. At week 12, Mg group was 60.8% higher in ultimate strength than the control group. Microindentation showed that, compared to the Control group, Mg group showed 49.9% higher Vickers hardness and 31% higher elastic modulus at week 8 and 12, respectively. At week 12, the new bone of Mg group remodelled to laminar bone, but those of the control group remained woven bonelike. Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group. |
| 关键词 | Patellar fracture Tension band wire Biodegradable implant Osteogenesis Microindentation |
| 资助者 | Chinese Academy of Sciences-Croucher Funding Scheme for Joint Laboratory ; University Grant Committee of the Hong Kong Special Administrative Region, China |
| DOI | 10.1016/j.bioactmat.2021.03.044 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Chinese Academy of Sciences-Croucher Funding Scheme for Joint Laboratory[CAS14303] ; University Grant Committee of the Hong Kong Special Administrative Region, China[C4026-17W] ; University Grant Committee of the Hong Kong Special Administrative Region, China[T13-402/17-N] |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| WOS记录号 | WOS:000685107200037 |
| 出版者 | KEAI PUBLISHING LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/159242 |
| 专题 | 中国科学院金属研究所 |
| 通讯作者 | Qin, Ling |
| 作者单位 | 1.Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Musculoskeletal Res Lab, Shatin, Hong Kong, Peoples R China 2.Chinese Univ Hong Kong, Innovat Orthopaed Biomat & Drug Translat Res Lab, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China 4.Dongguan Univ Technol, Sch Mat Sci & Engn, Dongguan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chow, Dick Ho Kiu,Wang, Jiali,Wan, Peng,et al. Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits[J]. BIOACTIVE MATERIALS,2021,6(11):4176-4185. |
| APA | Chow, Dick Ho Kiu.,Wang, Jiali.,Wan, Peng.,Zheng, Lizhen.,Ong, Michael Tim Yun.,...&Qin, Ling.(2021).Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits.BIOACTIVE MATERIALS,6(11),4176-4185. |
| MLA | Chow, Dick Ho Kiu,et al."Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits".BIOACTIVE MATERIALS 6.11(2021):4176-4185. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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