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Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel
Alternative TitleEffects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel
Gu, RuoXi; Wang, XiaoZeng; Li, Jing; Deng, Jie; Li, XingXing; Wang, Jiao
2016-01-01
Source PublicationMILITARY MEDICAL RESEARCH
ISSN2095-7467
Volume3Issue:1
AbstractBackground: This study evaluated the effect of omeprazole or pantoprazole on platelet reactivity in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients receiving clopidogrel.
Other AbstractBackground This study evaluated the effect of omeprazole or pantoprazole on platelet reactivity in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients receiving clopidogrel. Methods Consecutive patients with NSTE-ACS ( n ?=?620) from general hospital of Shenyang Military Command were randomized to the omeprazole or pantoprazole (20mg Results There were no significant differences between both the groups in platelet response to clopidogrel at 12–24h after drug administration (54.09%?±?18.90% vs 51.62%?±?19.85%, P ?=?0.12), 72h after PCI (52.15%?±?19.45% vs 49.66%?±?20.05%, P ?=?0.18), and 30days after PCI (50.44%?±?14.54% vs 48.52%?±?15.08%, P ?=?0.17). The rate of AEs did not differ significantly between groups during the 30-day (15.2% vs 14.8%, P ?=?0.91) and 180-day (16.5% vs 14.5%, P ?=?0.50) follow-up periods after PCI. Conclusions The addition of omeprazole or pantoprazole to clopidogrel did not restrict the effect of platelet aggregation by reducing the conversion of clopidogrel. Compared with clopidogrel alone, pantoprazole-clopidogrel and omeprazole-clopidogrel combinations did not increase the incidence of adverse clinical events during 30-day and 180-day follow-up periods after PCI. Trial registration The study is registered in the National Institutes of Health website with identifier NCT01735227 . Registered 14 November 2012.
Language英语
Funding Project[National Key Technology R&D Program in the "Twelfth Five-Year" Plan of China]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/159374
Collection中国科学院金属研究所
AffiliationInstitute of Metal Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Gu, RuoXi,Wang, XiaoZeng,Li, Jing,et al. Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel[J]. MILITARY MEDICAL RESEARCH,2016,3(1).
APA Gu, RuoXi,Wang, XiaoZeng,Li, Jing,Deng, Jie,Li, XingXing,&Wang, Jiao.(2016).Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel.MILITARY MEDICAL RESEARCH,3(1).
MLA Gu, RuoXi,et al."Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel".MILITARY MEDICAL RESEARCH 3.1(2016).
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