Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding | |
其他题名 | Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding |
Xie, Bing; Liang, Ming; Zhou, DaPeng; Zhao, Wen; Sun, JingYang; Rong, JingJing; Tian, Jing | |
2016-01-01 | |
发表期刊 | MILITARY MEDICAL RESEARCH
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ISSN | 2095-7467 |
卷号 | 3期号:1 |
摘要 | Background: Pelvic fracture combined with massive bleeding (PFCMB) is a complex issue in clinical practice. Currently, the use of angiography and embolization for the treatment of PFCMB obtains good results. The aim of this study is to observe the effects of early internal iliac artery embolization on the SIRS in dogs with simulated-pelvic-fracture combined with massive bleeding. |
其他摘要 | Background Pelvic fracture combined with massive bleeding (PFCMB) is a complex issue in clinical practice. Currently, the use of angiography and embolization for the treatment of PFCMB obtains good results. The aim of this study is to observe the effects of early internal iliac artery embolization on the SIRS in dogs with simulated-pelvic-fracture combined with massive bleeding. Methods Twenty adult dogs were randomly divided into an embolization group (EG) and a control group (CG). For the two groups, heart rate, respiratory rate and body temperature and other physiological variables were measured, and IL-6, TNF-α and arterial blood gas levels were monitored. These variables were assayed every 30min until death in the CG, while dogs in the EG underwent arterial angiography after 60min of modeling. The internal iliac artery was embolized on the injured side. Results The average time to SIRS in the CG was 3.56h, occurring at a rate of 90% (9 P ?0.05). In the two groups, the respiratory rate and leukocyte levels were higher at each monitored time after modeling than those before modeling; the mean arterial pressure, levels of hemoglobin and oxygen partial pressure were significantly lower at each time point after modeling than those before modeling except for the mean arterial pressure at 0h in EG; the platelet levels at 4 and 8h were higher than those before modeling; and the differences were statistically significant ( P ?0.05). In the EG, the mean arterial pressure, heart rate, respiratory rate and hemoglobin levels at 2 , 4 and 8h were lower than those at 0h; the levels of leukocytes, platelets and carbon dioxide partial pressure at 4 and 8h after modeling were higher than those at 0h, and the differences were statistically significant ( P ?0.05, P ?0.01); in the CG after modeling, the mean arterial pressure, levels of hemoglobin and carbon dioxide partial pressure at 2, 4 and 8h were lower than those at 0h; the levels of heart rate and leukocytes were higher than those before modeling; the respiratory rate and platelet levels at 4 and 8h were higher than those at 0h; and the differences were statistically significant ( P ?0.05). The levels of the mean arterial pressure and hemoglobin at 4 and 8h and the pH values at 8h after modeling in the EG were significantly higher than those in the CG, while the heart rate and respiratory rate at 4 and 8h were significantly lower than those in the CG. The pH values at 8h after modeling were significantly lower than those of the other monitored times in the CG ( P ?0.05, P ?0.01). The two groups had elevated levels of alkaline phosphatase after injury induction. Conclusion Through the use of an on-spot interventional treatment cabin, early internal iliac artery embolization can control bleeding associated with pelvic fractures, delay the occurrence of SIRS, and improve the success rate of the treatment of pelvic fracture combined with bleeding. |
语种 | 英语 |
资助项目 | [Key Project of "the Twelfth Five-Year Plan" for Medical Science and Technology Research of People's Liberation Army] ; [Scientific Key Project of Liaoning Province] |
文献类型 | 期刊论文 |
条目标识符 | http://ir.imr.ac.cn/handle/321006/159440 |
专题 | 中国科学院金属研究所 |
作者单位 | Institute of Metal Research, Chinese Academy of Sciences |
推荐引用方式 GB/T 7714 | Xie, Bing,Liang, Ming,Zhou, DaPeng,et al. Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding[J]. MILITARY MEDICAL RESEARCH,2016,3(1). |
APA | Xie, Bing.,Liang, Ming.,Zhou, DaPeng.,Zhao, Wen.,Sun, JingYang.,...&Tian, Jing.(2016).Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding.MILITARY MEDICAL RESEARCH,3(1). |
MLA | Xie, Bing,et al."Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding".MILITARY MEDICAL RESEARCH 3.1(2016). |
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