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Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5
Alternative TitleNetrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5
Jiuxu Bai; Junfeng Hao; Xiaoling Zhang; Hanmin Cui; Jingming Han; Ning Cao
2016-01-01
Source PublicationBMC Nephrology
ISSN1471-2369
Volume17Issue:1
AbstractEndothelial-to-mesenchymal transition (EndoMT) is a crucial event during kidney interstitial fibrosis and it is believed to be inhibited by netrin-1. Our aim was to determine the influence of netrin-1 on renal EndoMT in chronic kidney disease by studying its effect in 5/6 nephrectomized (Nx) rats.
Other AbstractBackground Endothelial-to-mesenchymal transition (EndoMT) is a crucial event during kidney interstitial fibrosis and it is believed to be inhibited by netrin-1. Our aim was to determine the influence of netrin-1 on renal EndoMT in chronic kidney disease by studying its effect in 5 Methods Male Sprague–Dawley rats were divided into three groups (10 rats Results Renal function and histopathological damage were significantly improved in Ad-netrin-1-treated 5 + + cells increased, which indicated EndoMT. However, the percentage of CD31 + + cells were reduced in the netrin-1-treated 5 Conclusion From the results, it seems that netrin-1 attenuates the progression of renal dysfunction by inhibiting EndoMT in 5
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/159508
Collection中国科学院金属研究所
AffiliationInstitute of Metal Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jiuxu Bai,Junfeng Hao,Xiaoling Zhang,et al. Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5[J]. BMC Nephrology,2016,17(1).
APA Jiuxu Bai,Junfeng Hao,Xiaoling Zhang,Hanmin Cui,Jingming Han,&Ning Cao.(2016).Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5.BMC Nephrology,17(1).
MLA Jiuxu Bai,et al."Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5".BMC Nephrology 17.1(2016).
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