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Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo
Erisen, Deniz Eren1,2; Zhang, Yuqi3; Zhang, Bingchun2; Yang, Ke2; Chen, Shanshan2; Wang, Xiaolin3
Corresponding AuthorYang, Ke(kyang@imr.ac.cn) ; Chen, Shanshan(sschen@imr.ac.cn) ; Wang, Xiaolin(wangxl80@126.com.cn)
2021-07-08
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
ISSN1552-4973
Pages10
AbstractBiosafety of AZ31B magnesium (Mg) alloy and the effect of its degradation products on tissues, organs, and whole systems are highly needed to be evaluated before clinical application. This study serves a wide variety of safety evaluations of biodegradable AZ31B alloy on nerve cells. As a result of this in vitro study, the maximum aluminum (Al) ion and Mg ion concentrations in the medium were estimated to be 22 mu mol/L and 2.75 mmol/L, respectively, during degradation. In addition, the corresponding cell mortality was observed to be 36% and lower than 5% according to the resistance curves of the cell to Mg and Al ions. Furthermore, the maximum Al ion and Mg ion concentrations in serum and cerebrospinal fluid were detected to be 26.1 mu mol/L and 1.2 mmol/L, respectively, for 5 months implantation. Combining the result of in vivo dialysis with the result of ion tolerance assay experiments, the actual death rate of nerve cells is estimated between 4 and 10% in vivo, which is lower than the result of in vitro cytotoxicity evaluation. Moreover, no psychomotor disability during clinical studies is observed. Consequently, stent made of AZ31B alloy with surface treatment is feasible for carotid artery stenosis, and it is safe in terms of cell viability on the nervous system.
Keywordbiodegradable cytotoxicity magnesium alloy metal ions vascular stents
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China
DOI10.1002/jbm.b.34907
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFC1102404] ; National Natural Science Foundation of China[51901227]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000670600400001
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/160013
Collection中国科学院金属研究所
Corresponding AuthorYang, Ke; Chen, Shanshan; Wang, Xiaolin
Affiliation1.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
3.Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing 100853, Peoples R China
Recommended Citation
GB/T 7714
Erisen, Deniz Eren,Zhang, Yuqi,Zhang, Bingchun,et al. Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2021:10.
APA Erisen, Deniz Eren,Zhang, Yuqi,Zhang, Bingchun,Yang, Ke,Chen, Shanshan,&Wang, Xiaolin.(2021).Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,10.
MLA Erisen, Deniz Eren,et al."Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021):10.
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