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Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria
Zhang, Xinrui1,2; Yang, Chunguang2; Xi, Tong2; Zhao, Jinlong2; Yang, Ke2
Corresponding AuthorYang, Chunguang(cgyang@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
2021-01-20
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume13Issue:2Pages:2303-2315
AbstractNumerous studies have found that the surface topography affects the material antibacterial properties by reducing the attachment of bacteria on the surfaces without influencing the viability of the adhered cells. For Cu-bearing alloys with excellent contact-killing properties, bacterial adhesion on the surface is also accompanied by short-range interactions which regulate the toxic effects of the material surface against bacterial cells. Thus, the surface topography of Cu-bearing alloys, as an important factor dominating the exposure level of bacteria on the surfaces, should affect the subsequent contact-killing efficiency. In this work, our major focus was on the regulation mechanism of the surface features on the material-bacterial interactions. We correlated the surface properties including different surface roughnesses of Cu-bearing stainless steel (SS) with the bacterial damage pattern and attempted to clarify the role of surface roughness in mediating the contact-killing behavior of Cu-bearing SS. The results of both atomic force microscopy and scanning electron microscopy investigations showed that E. coil cells experienced the most rapid physical and mechanical damages after incubating with the diamond-polished Cu-bearing SS surface. The bacterial cells noticeably stiffened and the adhesion force significantly increased, as evidenced by force-distance curve measurements. Because of the enhanced hydrophobicity and higher surface potential of the diamond-polished surface, which strengthened the Lew is acid-base attractive forces and weakened the electrostatic barrier between the bacteria and the surface, a higher exposure surface for bacteria was generated. Furthermore, the contact-induced charge transfer, manifested by Cu ion burst release, and reactive oxygen species over expression contribute to an efficient contact-killing process.
KeywordCu-bearing stainless steel surface roughness contact killing biomechanical performances interfacial interaction
Funding OrganizationNational Natural Science Foundation of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association CAS ; Shi-changxu Innovation Center for Advanced Materials
DOI10.1021/acsami.0c19655
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[51771199] ; National Natural Science Foundation of China[51631009] ; National Natural Science Foundation of China[U1906226] ; National Key Research and Development Program of China[2016YFB0300205] ; Youth Innovation Promotion Association CAS[2018221] ; Shi-changxu Innovation Center for Advanced Materials
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000612551400015
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/160632
Collection中国科学院金属研究所
Corresponding AuthorYang, Chunguang; Yang, Ke
Affiliation1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xinrui,Yang, Chunguang,Xi, Tong,et al. Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(2):2303-2315.
APA Zhang, Xinrui,Yang, Chunguang,Xi, Tong,Zhao, Jinlong,&Yang, Ke.(2021).Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria.ACS APPLIED MATERIALS & INTERFACES,13(2),2303-2315.
MLA Zhang, Xinrui,et al."Surface Roughness of Cu-Bearing Stainless Steel Affects Its Contact-Killing Efficiency by Mediating the Interfacial Interaction with Bacteria".ACS APPLIED MATERIALS & INTERFACES 13.2(2021):2303-2315.
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