| Biological applications of copper-containing materials | |
| Wang, Peng1; Yuan, Yonghui2; Xu, Ke1; Zhong, Hongshan1; Yang, Yinghui4; Jin, Shiyu1; Yang, Ke3; Qi, Xun1 | |
| Corresponding Author | Yang, Ke(kyang@imr.ac.cn) ; Qi, Xun(qixun716@hotmail.com) |
| 2021-04-01 | |
| Source Publication | BIOACTIVE MATERIALS
 |
| Volume | 6Issue:4Pages:916-927 |
| Abstract | Copper is an indispensable trace metal element in the human body, which is mainly absorbed in the stomach and small intestine and excreted into the bile. Copper is an important component and catalytic agent of many enzymes and proteins in the body, so it can influence human health through multiple mechanisms. Based on the biological functions and benefits of copper, an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials, which exhibit unique properties in protecting the cardiovascular system, promoting bone fracture healing, and exerting antibacterial effects. Copper can also be used in promoting incisional wounds healing, killing cancer cells, Positron Emission Tomography (PET) imaging, radioimmunological tracing and radiotherapy of cancer. In the present review, the biological functions of copper in the human body are presented, along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials. Furthermore, this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications. |
| Keyword | Copper Biomaterials Angiogenesis Osteogenesis Antibacterial |
| Funding Organization | National Natural Science Foundation of China ; Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center ; Key Research and Serving Local Area Projects of the Educational Department of Liaoning Province, China |
| DOI | 10.1016/j.bioactmat.2020.09.017 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[81873918] ; National Natural Science Foundation of China[51631009] ; Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center[18-006-9-01] ; Key Research and Serving Local Area Projects of the Educational Department of Liaoning Province, China[ZF2019005] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| WOS ID | WOS:000616630300002 |
| Publisher | KEAI PUBLISHING LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/160673 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Yang, Ke; Qi, Xun |
| Affiliation | 1.China Med Univ, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China 2.China Med Univ, Clin Res Ctr Malignant Tumor Liaoning Prov, Canc Hosp, Liaoning Canc Hosp & Inst, Shenyang 110042, Liaoning, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Suzhou Silvan Med Co Ltd, Suzhou 215006, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Peng,Yuan, Yonghui,Xu, Ke,et al. Biological applications of copper-containing materials[J]. BIOACTIVE MATERIALS,2021,6(4):916-927. |
| APA | Wang, Peng.,Yuan, Yonghui.,Xu, Ke.,Zhong, Hongshan.,Yang, Yinghui.,...&Qi, Xun.(2021).Biological applications of copper-containing materials.BIOACTIVE MATERIALS,6(4),916-927. |
| MLA | Wang, Peng,et al."Biological applications of copper-containing materials".BIOACTIVE MATERIALS 6.4(2021):916-927. |
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