Biological applications of copper-containing materials
Wang, Peng1; Yuan, Yonghui2; Xu, Ke1; Zhong, Hongshan1; Yang, Yinghui4; Jin, Shiyu1; Yang, Ke3; Qi, Xun1
Corresponding AuthorYang, Ke( ; Qi, Xun(
AbstractCopper is an indispensable trace metal element in the human body, which is mainly absorbed in the stomach and small intestine and excreted into the bile. Copper is an important component and catalytic agent of many enzymes and proteins in the body, so it can influence human health through multiple mechanisms. Based on the biological functions and benefits of copper, an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials, which exhibit unique properties in protecting the cardiovascular system, promoting bone fracture healing, and exerting antibacterial effects. Copper can also be used in promoting incisional wounds healing, killing cancer cells, Positron Emission Tomography (PET) imaging, radioimmunological tracing and radiotherapy of cancer. In the present review, the biological functions of copper in the human body are presented, along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials. Furthermore, this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.
KeywordCopper Biomaterials Angiogenesis Osteogenesis Antibacterial
Funding OrganizationNational Natural Science Foundation of China ; Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center ; Key Research and Serving Local Area Projects of the Educational Department of Liaoning Province, China
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81873918] ; National Natural Science Foundation of China[51631009] ; Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center[18-006-9-01] ; Key Research and Serving Local Area Projects of the Educational Department of Liaoning Province, China[ZF2019005]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000616630300002
Citation statistics
Cited Times:71[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYang, Ke; Qi, Xun
Affiliation1.China Med Univ, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China
2.China Med Univ, Clin Res Ctr Malignant Tumor Liaoning Prov, Canc Hosp, Liaoning Canc Hosp & Inst, Shenyang 110042, Liaoning, Peoples R China
3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
4.Suzhou Silvan Med Co Ltd, Suzhou 215006, Peoples R China
Recommended Citation
GB/T 7714
Wang, Peng,Yuan, Yonghui,Xu, Ke,et al. Biological applications of copper-containing materials[J]. BIOACTIVE MATERIALS,2021,6(4):916-927.
APA Wang, Peng.,Yuan, Yonghui.,Xu, Ke.,Zhong, Hongshan.,Yang, Yinghui.,...&Qi, Xun.(2021).Biological applications of copper-containing materials.BIOACTIVE MATERIALS,6(4),916-927.
MLA Wang, Peng,et al."Biological applications of copper-containing materials".BIOACTIVE MATERIALS 6.4(2021):916-927.
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