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Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer
Bao, Zhihong1; Li, Kexin1; Hou, Peipei2; Xiao, Ru3; Yuan, Yue1; Sun, Zhenhua3
Corresponding AuthorBao, Zhihong(baozhihong@syphu.edu.cn) ; Sun, Zhenhua(zhsun@imr.ac.cn)
2021-02-21
Source PublicationMATERIALS CHEMISTRY FRONTIERS
Volume5Issue:4Pages:1632-1654
AbstractPhototherapy, a light-induced method, involves photodynamic therapy (PDT) and photothermal therapy (PTT). Recently, PDT and PTT have attracted significant attention due to their non-invasiveness, minimal side effects and high spatial selectivity upon localized irradiation at the tumor sites. Owing to the unique characters of nanoscale metal-organic frameworks (nMOFs) associated with excellent loading, versatile surface chemistries, enhanced permeability and retention effect and biodegradability, nMOFs are very suitable for biomedical applications. Importantly, the periodic porous structure of nMOFs can effectively avoid the self-aggregation and self-quenching of photosensitizers in PDT, and enhance the photothermal responses and heat stability of photothermal agents in PTT. These specific merits of the nMOFs have enabled them as an ideal platform for cancer phototherapy. This review mainly discusses and summarizes the advancement of MOF-based nanocomposites as a therapeutic platform for cancer phototherapy or synergistic phototherapy within the last five years. In addition, this review also focused on the interrelationship between the structure and application of MOF-based composites. The remaining challenges and future opportunities in this field are also highlighted.
Funding OrganizationNatural Science Foundation of Liaoning Province of China ; Research Project of Science and Technology of the Department of Education of Liaoning Province ; Project of Shenyang Key Laboratory of Functional Drug Carrier Materials ; Youth Innovation Promotion Association of the Chinese Academy of Sciences
DOI10.1039/d0qm00786b
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of Liaoning Province of China[2020-MS-188] ; Research Project of Science and Technology of the Department of Education of Liaoning Province[2019LJC01] ; Project of Shenyang Key Laboratory of Functional Drug Carrier Materials[19-110-4-08] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[Y201942]
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Materials Science, Multidisciplinary
WOS IDWOS:000621097700006
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/160960
Collection中国科学院金属研究所
Corresponding AuthorBao, Zhihong; Sun, Zhenhua
Affiliation1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang Key Lab Funct Drug Carrier Mat, Shenyang 110016, Peoples R China
2.China Med Univ, Peoples Hosp Liaoning Prov, Peoples Hosp, Dept Cardiol, Shenyang 110016, Peoples R China
3.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Bao, Zhihong,Li, Kexin,Hou, Peipei,et al. Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer[J]. MATERIALS CHEMISTRY FRONTIERS,2021,5(4):1632-1654.
APA Bao, Zhihong,Li, Kexin,Hou, Peipei,Xiao, Ru,Yuan, Yue,&Sun, Zhenhua.(2021).Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer.MATERIALS CHEMISTRY FRONTIERS,5(4),1632-1654.
MLA Bao, Zhihong,et al."Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer".MATERIALS CHEMISTRY FRONTIERS 5.4(2021):1632-1654.
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