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The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration
Zhang, Nan1,4; Wang, Weidan2,3; Zhang, Xiuzhi2; Nune, Krishna C.5; Zhao, Ying6; Liu, Na1; Misra, R. D. K.5; Yang, Ke3; Tan, Lili3; Yan, Jinglong4
Corresponding AuthorYang, Ke(kyang@imr.ac.cn) ; Tan, Lili(lltan@imr.ac.cn) ; Yan, Jinglong(yjlg4@aliyun.com)
2021-06-01
Source PublicationBIOACTIVE MATERIALS
Volume6Issue:6Pages:1765-1776
AbstractRegeneration of long-bone segmental defects remains a challenge for orthopedic surgery. Current treatment options often require several revision procedures to maintain acceptable alignment and achieve osseous healing. A novel hollow tubular system utilizing magnesium-strontium (Mg-Sr) alloy with autogenous morselized bone filled inside to repair segmental defects was developed. To improve the corrosion and biocompatible properties, two coatings, Ca-P and Sr-P coatings, were prepared on surface of the implants. Feasibility of applying these coated implants was systematically evaluated in vitro and in vivo, and simultaneously to have a better understanding on the relationship of degradation and bone regeneration on the healing process. According to the in vitro corrosion study by electrochemical measurements, greater corrosion resistance was obtained for Ca-P coated sample, and attributed to the double-layer protective structure. The cytotoxicity and alkaline phosphatase (ALP) assays demonstrated enhanced bioactivity for Sr-P coated group because of the long-lasting release of beneficial Sr2+. At 12 weeks post-implantation with Mg-Sr alloy porous device, the segmental defects were effectively repaired with respect to both integrity and continuity. In addition, compared with the Ca-P coated implant, the Sr-P coated implant was more proficient at promoting bone formation and mineralization. In summary, the Sr-P coated implants have bioactive properties and exceptional durability, and promote bone healing that is close to the natural rate, implying their potential application for the regeneration of segmental defects.
KeywordMagnesium-strontium alloy Segmental defect Degradation behavior Bone regeneration
Funding OrganizationBasic Research Project from the Education Office of Heilongjiang Province ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement ; Institute of Metal Research, Chinese Academy of Sciences ; National Natural Science Foundation of China
DOI10.1016/j.bioactmat.2020.11.026
Indexed BySCI
Language英语
Funding ProjectBasic Research Project from the Education Office of Heilongjiang Province[2017KYYWF-0738] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1100604] ; Institute of Metal Research, Chinese Academy of Sciences[2015-ZD01] ; National Natural Science Foundation of China[31500777] ; National Natural Science Foundation of China[81472107]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000630522400020
PublisherKEAI PUBLISHING LTD
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/162154
Collection中国科学院金属研究所
Corresponding AuthorYang, Ke; Tan, Lili; Yan, Jinglong
Affiliation1.Qiqihar Med Univ, Dept Orthoped Surg, Affiliated Hosp 2, Qiqihar 161000, Peoples R China
2.Dalian Univ, Dept Orthopaed, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
4.Harbin Med Univ, Dept Orthoped Surg, Affiliated Hosp 2, Harbin 150081, Peoples R China
5.Univ Texas El Paso, Dept Met Mat & Biomed Engn, El Paso, TX 79968 USA
6.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Nan,Wang, Weidan,Zhang, Xiuzhi,et al. The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration[J]. BIOACTIVE MATERIALS,2021,6(6):1765-1776.
APA Zhang, Nan.,Wang, Weidan.,Zhang, Xiuzhi.,Nune, Krishna C..,Zhao, Ying.,...&Yan, Jinglong.(2021).The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration.BIOACTIVE MATERIALS,6(6),1765-1776.
MLA Zhang, Nan,et al."The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration".BIOACTIVE MATERIALS 6.6(2021):1765-1776.
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