Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction

doi:10.1016/j.matchemphys.2021.125219

IMR OpenIR

	Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction
	Ullah, Ihsan 1,2; Xu, Qian 1,3; Jan, Haseen Ullah 4; Ren, Ling 1; Yang, Ke 1
通讯作者	Ren, Ling(lren@imr.ac.cn)
	2022
发表期刊	MATERIALS CHEMISTRY AND PHYSICS
ISSN	0254-0584
卷号	275 页码:13
摘要	Recently the use of Sr2+ and Zn2+ ions substituted HA as an excellent biomaterial has been reported. To expand the usage to load-bearing applications, like hip replacement, it has been proposed that the material should be used in the form of a coating on the implant surface. In this work, we prepared Sr2+ and Zn2+ co-substituted HA plasma spray coating at different concentrations on titanium alloy (Ti-6Al-4V). All coatings showed excellent bonding strength with the substrate. The apatite layer formation on the coatings was studied via immersion in SBF. All samples exhibited great capability to induce the apatite layer formation on the coating surface, however, 10Zn5Sr-HA coating inhibited the apatite layer formation. The cell material interaction on the surfaces of the coatings was examined through MC3T3-E1 cell and demonstrated higher biocompatibility, protein adsorption ability, and significantly higher dissolution rate than pure HA coating. However, 10Zn5Sr-HA coating shows cytotoxicity which is confirmed by cell proliferation, cell adhesion, and ALP activity. Besides, some dead cells and poor cellular morphology were also found on the coating surface. The co-substituted HA coating revealed excellent antibacterial ability against bacterial colonization. The addition of Sr2+ to the Zn-HA coating effectively decreased the thermal instability, cytotoxicity, and increased performance as compared to HA coating. From the results, it is indicated that the 5Zn10Sr-HA coating has good bonding strength, bioactivity, biocompatibility, and antibacterial properties.
关键词	Hydroxyapatite coating Plasma spraying Cytotoxicity Bioactivity Antibacterial
资助者	Key Projects for Foreign Cooperation of Bureau of International Cooperation, Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Liaoning Revitalization Talents Program
DOI	10.1016/j.matchemphys.2021.125219
收录类别	SCI
语种	英语
资助项目	Key Projects for Foreign Cooperation of Bureau of International Cooperation, Chinese Academy of Sciences[174321KYSB20180006] ; National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation of China[51631009] ; National Natural Science Foundation of China[31870954] ; Liaoning Revitalization Talents Program[XLYC1807069]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:000705723800002
出版者	ELSEVIER SCIENCE SA
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/166582
专题	中国科学院金属研究所
通讯作者	Ren, Ling
作者单位	1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, Shenzhen 518055, Guangdong, Peoples R China 3.Northeastern Univ, Sch Mat & Engn, Dept Mat Phys & Chem, Key Lab Anisotropy & Texture Mat,Minist Educ, Shenyang 110819, Peoples R China 4.Univ Engn & Technol, Peshawar, Khyber Pakhtunk, Pakistan
推荐引用方式 GB/T 7714	Ullah, Ihsan,Xu, Qian,Jan, Haseen Ullah,et al. Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction[J]. MATERIALS CHEMISTRY AND PHYSICS,2022,275:13.
APA	Ullah, Ihsan,Xu, Qian,Jan, Haseen Ullah,Ren, Ling,&Yang, Ke.(2022).Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction.MATERIALS CHEMISTRY AND PHYSICS,275,13.
MLA	Ullah, Ihsan,et al."Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction".MATERIALS CHEMISTRY AND PHYSICS 275(2022):13.