| Construction of bio-functional Mg/HA composite layered coating for orthopedic application | |
| Wan Peng1,2; Yan Xudong3; Li Mei4; Zhao Mingchun3; Zhang Yu4; Yang Ke2 | |
| Corresponding Author | Wan Peng(wanpeng@dgut.edu.cn) ; Yang Ke(kyang@imr.ac.cn) |
| 2021-09-26 | |
| Source Publication | SCIENCE CHINA-TECHNOLOGICAL SCIENCES
 |
| ISSN | 1674-7321 |
| Pages | 10 |
| Abstract | Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and HA composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The HA transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/HA coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/HA coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/HA coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/HA composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants. |
| Keyword | magnesium HA composite layered coating titanium orthopedic bio-function |
| Funding Organization | National Natural Science Foundation of China ; Research Start-up Funds of DGUT ; Characteristic Innovation Project of University in Guangdong |
| DOI | 10.1007/s11431-020-1762-3 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31500777] ; Research Start-up Funds of DGUT[GC300501-082] ; Characteristic Innovation Project of University in Guangdong[2020KTSCX148] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Multidisciplinary ; Materials Science, Multidisciplinary |
| WOS ID | WOS:000702976900001 |
| Publisher | SCIENCE PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/166700 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Wan Peng; Yang Ke |
| Affiliation | 1.Dongguan Univ Technol, Sch Mat Sci & Engn, Dongguan 523808, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Cent South Univ, Sch Mat Sci & Engn, Changsha 410083, Peoples R China 4.Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Res Ctr Med Sci, Guangzhou 510080, Peoples R China |
| Recommended Citation GB/T 7714 | Wan Peng,Yan Xudong,Li Mei,et al. Construction of bio-functional Mg/HA composite layered coating for orthopedic application[J]. SCIENCE CHINA-TECHNOLOGICAL SCIENCES,2021:10. |
| APA | Wan Peng,Yan Xudong,Li Mei,Zhao Mingchun,Zhang Yu,&Yang Ke.(2021).Construction of bio-functional Mg/HA composite layered coating for orthopedic application.SCIENCE CHINA-TECHNOLOGICAL SCIENCES,10. |
| MLA | Wan Peng,et al."Construction of bio-functional Mg/HA composite layered coating for orthopedic application".SCIENCE CHINA-TECHNOLOGICAL SCIENCES (2021):10. |
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